Acute-on chronic liver failure.

By R. Jalan, P. Ginés, J. Olson, Rajeshwar P. Mookerjee, R. Moreau, G. Garcia‐Tsao, V. Arroyo, P. Kamath. Journal of Hepatology, 2012

1,212 citations recorded by the source corpus.

Acute-on-chronic liver failure (ACLF) is an increasingly recognised entity encompassing an acute deterioration of liver function in patients with cirrhosis, which is usually associated with a precipitating event and results in the failure of one or more organs and high short term mortality. Prospective data to define this is lacking but there is a large body of circumstantial evidence suggesting that this condition is a distinct clinical entity. From the pathophysiologic perspective, altered host response to injury and infection play important roles in its development. This review focuses upon the current understanding of this syndrome from the clinical, prognostic and pathophysiologic perspectives and indicates potential biomarkers and therapeutic targets for intervention.

Subfields: Epidemiology, Hepatology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/bc31d6223e7b6aa9125e9498779b941647fb1680

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. P. Ginés
2. M. Bernardi
3. Danyang Li
4. Minghua Wu
5. J. Trebicka
6. W. Laleman
7. P. Angeli
8. Rajeshwar P. Mookerjee

In Hepatology

1. P. Ginés
2. M. Bernardi
3. J. Trebicka
4. W. Laleman
5. P. Angeli
6. Rajeshwar P. Mookerjee

Citations in the corpus

• Clinical Course of acute‐on‐chronic liver failure syndrome and effects on prognosis (2015, methodology): “Median delay between ACLF diagnosis and LT was 11 (1-28) days.”
• Pattern recognition receptors in health and diseases (2021, background): “The initial stage usually manifests as fatty liver, which can then develop into alcoholic hepatitis, liver fibrosis, and cirrhosis.(392,393) Patients with advanced alcoholic cirrhosis are more susceptible to infection.”
• Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL) 2014 (2009, neutral): “Another logistic regression model [105] using five independent factors, namely HE, HRS, liver cirrhosis, HBeAg, and PTA, gave an AUC of 0.873, as compared to a MELD AUC of 0.694.”
• Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update (2019, background): “Liver transplant survival has been shown to be above 90% in patients with HBV reactivation [162].”
• The Global Burden of Liver Disease: The Major Impact of China (2014, background): “Acute-on-chronic liver failure is a unique clinical entity that is characterized by acute decompensation of compensated or decompensated cirrhosis, with a poor prognosis and high short-term mortality.(39,40) However, no consensus has been achieved for acute-on-chronic liver failure among Western and”
• Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure. (2014, background): “In the US, about 200,000 patients with cirrhosis are hospitalised each year of which about 26,000 patients require ICU care [1,3,4].”