Signaling through the JAK/STAT pathway, recent advances and future challenges.

By T. Kisseleva, S. Bhattacharya, J. Braunstein, C. Schindler. Gene, 2002

1,186 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/9dbcd168a2d6021cf00239f9af0b1d864c44b529

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Garry P. Nolan
2. Peter O. Krutzik
3. Ann-Christine Syvänen
4. Nikesh Kotecha
5. Tiffany J. Chen

In Oncology

1. Garry P. Nolan
2. Peter O. Krutzik

In Pathology and Forensic Medicine

1. Garry P. Nolan
2. Peter O. Krutzik

Citations in the corpus

• The JAK/STAT signaling pathway: from bench to clinic (2021, background): “PIASx-α can act as an E3 ligase to modify the Lys703 SUMO of STAT1.”
• Intracellular phospho‐protein staining techniques for flow cytometry: Monitoring single cell signaling events (2003, methodology): “Therefore, we took a systematic approach to examining various intracellular phospho-protein staining protocols in two model systems, the mitogen-activated protein (MAP) kinase cascade in Jurkat T cells (21) and the Janus kinasesignal transducer and activator of transcription (Jak-Stat) pathway in mo”
• Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus. (2005, methodology): “Although we originally selected TYK2 for study because of its connection with the type I IFN system, it should be noted that TYK2 also interacts with the receptors for colony stimulating factor 1, angiotensin II, platelet-activating factor, and several interleukins (Kisseleva et al. 2002).”
• The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells (2017, background): “Central pseudokinase domain is named because of its homology to Protein Tyrosine Kinases (PTK) domain; however, it lacks of catalytic function and appears to have a regulatory role [20, 25].”
• STAT proteins: From normal control of cellular events to tumorigenesis (2003, background): “These include members of the SOCS family of counterregulatory proteins (Kile et al., 2001; Yamada et al., 2003), as well as, phosphatases and enzymes that medi- ate covalent modification of STAT proteins (Kisseleva et al., 2002).”