The genome sequence of the filamentous fungus Neurospora crassa
By James E. Galagan, Sarah E. Calvo, K. Borkovich, E. Selker, N. Read, David B. Jaffe, W. Fitzhugh, Li‐Jun Ma, S. Smirnov, S. Purcell and 67 more. Nature, 2003
1,709 citations recorded by the source corpus.
Neurospora crassa is a central organism in the history of twentieth-century genetics, biochemistry and molecular biology. Here, we report a high-quality draft sequence of the N. crassa genome. The approximately 40-megabase genome encodes about 10,000 protein-coding genes—more than twice as many as in the fission yeast Schizosaccharomyces pombe and only about 25% fewer than in the fruitfly Drosophila melanogaster. Analysis of the gene set yields insights into unexpected aspects of Neurospora biology including the identification of genes potentially associated with red light photobiology, genes implicated in secondary metabolism, and important differences in Ca2+ signalling as compared with plants and animals. Neurospora possesses the widest array of genome defence mechanisms known for any eukaryotic organism, including a process unique to fungi called repeat-induced point mutation (RIP). Genome analysis suggests that RIP has had a profound impact on genome evolution, greatly slowing the creation of new genes through genomic duplication and resulting in a genome with an unusually low proportion of closely related genes.
Subfields: Molecular Biology, Plant Science
View Paper: https://www.semanticscholar.org/paper/9d52734cdcf9ce0872a48ffdb65c55d526c0049b
How researchers see this paper
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In Molecular Biology
- Richard Durbin
- Andreas Ruepp
- Michele E. Clamp
- Hans-Werner Mewes
- S. Kryštofová
- Ewan Birney
- Stanley F. Nelson
- Steve Horvath
In Plant Science
- Richard Durbin
- Ewan Birney
- Mihai Pop
- Heng Li
- Steven L. Salzberg
- Rayan Chikhi
- Paul Medvedev
- Daniel R. Zerbino
Citations in the corpus
- Genome Sequencing and Comparative Transcriptomics of the Model Entomopathogenic Fungi Metarhizium anisopliae and M. acridum (2011, background): “These include putative a-mating type genes and genes with similarity to a high mobility group (HMG) mating type gene, suggesting that they may have the potential to be either self (homothallic) or non-self (heterothallic) fertile under favorable conditions [26].”
- The FunCat, a functional annotation scheme for systematic classification of proteins from whole genomes. (2004, background): “Eukaryotes Saccharomyces cerevisiae 6157 4033 (9) Neurospora crassa 8348 3713 (11) Arabidopsis thaliana 26444 17717 (14) Homo sapiens 24910 14633 http://www.”