Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

By K. Schluns, W. Kieper, S. Jameson, L. Lefrançois. Nature Immunology, 2000

1,858 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/9cee117453fe7c9d68117325636548c704c80e03

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Rafi Ahmed
2. E. Wherry
3. M. Bevan
4. S. Kaech
5. C. Surh
6. J. Wherry
7. W. Cui
8. W. Leonard

Citations in the corpus

• Interleukin 15 Is Required for Proliferative Renewal of Virus-specific Memory CD8 T Cells (2002, background): “1542 IL-15 in Memory CD8 T Cell Generation and Homeostatic Proliferation with specific antigen (14,15), or even MHC class I (16, 24).”
• Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. (2007, background): “Recent work identified IL-7R as a marker of MPECs following acute infections because at the peak of effector CD8 T cell expansion, ∼5−20% of antigen-specific CD8 T cells expressed IL-7R (referred to as IL-7Rhi) and had a significantly greater potential to form memory CD8 T cells when compared to IL-”
• Cytokine Requirements for Acute and Basal Homeostatic Proliferation of Naive and Memory CD8+ T Cells (2002, background): “Although we cannot rule out a role for TSLP, it is likely that the inhibition of homeostatic proliferation described herein was due to blocking of IL-7/IL-7R interactions as these results are in accord with those obtained when T cells were transferred into IL-7 / hosts (18, 19).”
• Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function (2005, background): “IL-7 is crucial for the survival and homeostatic expansion of naive CD8 T cells and also can contribute to memory CD8 T cell homeostasis (9, 10).”
• Reduced Expression of Bcl-2 in CD8+ T Cells Deficient in the IL-15 Receptor α-Chain1 (2002, background): “occurs normally in IL-7R memory CD8 cells (41).”
• Interleukin (IL)-15 and IL-7 Jointly Regulate Homeostatic Proliferation of Memory Phenotype CD8+ Cells but Are Not Required for Memory Phenotype CD4+ Cells (2002, background): “1530 IL-15 and IL-7 Regulation of Memory CD8 Cell Homeostasis sponse to antigen (9).”