A Membrane Receptor for Retinol Binding Protein Mediates Cellular Uptake of Vitamin A

By Riki Kawaguchi, Jiamei Yu, J. Honda, Jane G. Hu, J. Whitelegge, P. Ping, P. Wiita, D. Bok, Hui Sun. Science, 2007

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Interactions of nanomaterials and biological systems: implications to personalized nanomedicine (2012, background): “Similarly, the retinol-binding protein, which is constitutively expressed in the brain, the spleen, the eyes, the genital organs and in lower quantities in the heart and lungs, was recently exploited to target stellate cells in the liver to alleviate cirrhotic fibrosis [88, 89].”
A global perspective on carotenoids: Metabolism, biotechnology, and benefits for nutrition and health. (2018, background): “Extrahepatic organs such as the eye use the plasma membrane protein STRA6 (stimulated retinoic acid 6) as a high affinity RBP receptor for retinol uptake [401, 402].”
Spermatogenesis: The Commitment to Meiosis. (2016, background): “However, it has been shown that the Stra6 receptor is not essential for maintaining vitamin A homeostasis in any tissue other than the eye, and Stra6deficient mice have normal fertility (7).”
Retinoic acid in the development, regeneration and maintenance of the nervous system (2007, background): “Retinol is taken up by target cells through an interaction with a membrane receptor for RBP4, STRA6 (Ref”
The Retinal Pigment Epithelium in Health and Disease (2010, background): “It is also provided to RPE by serum retinol binding protein (SRBP) through the choroidal blood flow and subsequent interactions with the STRA6 receptor at the basal side of the RPE [98].”