Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer

By N. Dhillon, Bharat B. Aggarwal, R. Newman, R. Wolff, A. Kunnumakkara, J. Abbruzzese, C. Ng, V. Badmaev, Razelle Kurzrock. Clinical Cancer Research, 2008

1,264 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/9cc93616811b0ab1d2db5dbfe9338ff2b143f6d8

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Citations in the corpus

Curcumin: An Anti-Inflammatory Molecule from a Curry Spice on the Path to Cancer Treatment (2011, background): “, twenty-five patients each treated with 8000 mg per day curcumin orally for two months observed peaked plasma curcumin level from 22 to 41 ng/mL [119].”
Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases (2017, background): “…were recovered Irving et al., 2013 HNSCC 2 gd 39 Decreased IKKβ kinase activity in saliva Kim et al., 2011 Pancreatic 8 g·day 1; 8 weeks 25 Safe, well tolerated and efficacious Dhillon et al., 2008 8 g·day 1; 4 weeksb 17 Showed partial response and stable disease Epelbaum et al., 2010 8 g·day 1;…”
Curcumin and Cancer (2019, background): “Indeed, in one patient a stable disease for >18 months was observed and in another patient, a brief but marked, tumor regression (73%) was ascertained [90].”
Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors. (2014, background): “that this compound has useful biological activities in patients with pancreatic cancer [249].”
Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior (2012, background): “…(a derivative of the curry spice, turmeric), which has been shown to decrease NF-kB activation in the PBMCs of patients with pancreatic cancer (Dhillon et al, 2008); a tocopherol (a form of Vitamin E), which has been shown to block NF-kB and the associated neuroinflammatory and behavioral…”
Design of Curcumin Loaded PLGA Nanoparticles Formulation with Enhanced Cellular Uptake, and Increased Bioactivity in vitro and Superior Bioavailability in vivo (2009, neutral): “colon cancer [12,13], familial adenomatous polyposis (FAP) [14], pancreatic cancer [15], and multiple myeloma [16].”
Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. (2009, background): “Downregulation of NF-κB and COX-2 were also observed.(64) Currently there are nine ongoing clinical trials investigating the benefits of curcumin as a therapy for various cancers.”
Identification of Amyloid Plaques in Retinas from Alzheimer’s Patients and Noninvasive In Vivo Optical Imaging of Retinal Plaques in a Mouse Model (2010, neutral): “In terms of safety, Phase I and II trials using curcumin in patients with cancer have proven its low toxicity in humans even at high doses (12 g/day), and when given over extended periods of time (Dhillon et al., 2008).”