Molecular Mechanisms Activating the Nrf2-Keap1 Pathway of Antioxidant Gene Regulation

By Makoto Kobayashi, Masayuki Yamamoto. Antioxidants and Redox Signaling, 2005

1,100 citations recorded by the source corpus.

Subfields: Molecular Biology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/9ca30d1e24f87e2dc44d463d971c53467560543d

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Citations in the corpus

Combination therapy in combating cancer (2017, background): “Further, Nrf2 heterodimerizes with either MAF (proto-oncogene c-Maf), activating transcription factor (ATF) or AP-1 (activator protein-1 transcription factor) and subsequently binds to a specific promoter region (a cis-acting enhancer sequence (TCAG/CXXXGC), termed the antioxidant response element (”
Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response. (2009, background): “…of an intracellular antioxidant response through transcriptional activation of an array of genes, including phase II detoxifying enzymes, antioxidants, and transporters that protect cells from toxic and carcinogenic chemicals (Kensler et al., 2007; Kobayashi and Yamamoto, 2005; Zhang, 2006).”
Redox Regulation of Cell Survival (2008, neutral): “NF-E2–related factor 2 (Nrf2) is a member of p45 NF-E2–related proteins (p45 NF-E2, Nrf1, Nrf2, and Nrf3 (162, 163).”
The Impact of Oxidative Stress and Inflammation on RPE Degeneration in Non-neovascular AMD (2017, background): “The released Nrf2 then translocates to the nucleus, where it dimerizes with Maf proteins, and binds to the antioxidant response element (ARE) in the promoters of its target genes to initiate transcription (Dinkova-Kostova et al., 2005; Kobayashi and Yamamoto, 2005; Wakabayashi et al., 2003).”
The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds (2008, background): “Nrf2 target genes are multifarious and encode phase 2 detoxifying enzymes, antioxidant proteins, enzymes for glutathione biosynthesis, ABC transporters, scavenger receptors, transcription factors, proteases, chaperone proteins, and so forth (23).”
Small Molecule Modulators of Keap1-Nrf2-ARE Pathway as Potential Preventive and Therapeutic Agents (2012, background): “Carnosol (54) and its acid derivative, carnosic acid (55) are catechol-type abietane diterpenes from Rosmarinus officinalis (rosemary).”
Oxidative and Electrophilic Stresses Activate Nrf2 through Inhibition of Ubiquitination Activity of Keap1 (2006, background): “In defense, vertebrates have developed multiple stress response systems, including the system regulated by the Nrf2-Keap1 pathway (13, 21, 23, 24, 28, 29).”