TNF downmodulates the function of human CD4+CD25hi T-regulatory cells.

By X. Valencia, G. Stephens, R. Goldbach-Mansky, Mildred Wilson, E. Shevach, P. Lipsky. Blood, 2006

880 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/9c8f6ce15b50ce2547e2010acc0abff8e85d85e4

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In Immunology

1. Loise M. Francisco
2. P. Sage
3. Arlene H. Sharpe
4. E. Wherry
5. G. Freeman

Citations in the corpus

• Innate and adaptive immunity in inflammatory bowel disease. (2014, background): “In particular, Treg exert their function by producing the anti-inflammatory cytokines IL-10 and TGF-β and by preventing both the activation and the effector function of T cells that have escaped other mechanisms of tolerance [81].”
• Mesenchymal stem cells: mechanisms of inflammation. (2011, background): “A particularly interesting and important observation in the field of arthritis is that TNF-α can downmodulate the function of CD4+CD25+ Tregs; anti-TNF-α antibodies increase FoxP3 messenger RNA and protein expression (36).”
• The PD-1 Pathway in Tolerance and Autoimmunity (2010, background): “When CNS-infiltrating tetramer-positive Tregs were combined with MOG tetramer-reactive T effector cells, Tregs could no longer maintain suppressive function, at least in part owing to the production of pro-inflammatory cytokines (IL-6 and TNF-a) that may overwhelm the suppressive capacity of Tregs (”