Structural, chemical and biological aspects of antioxidants for strategies against metal and metalloid exposure
By S. Flora. Oxidative Medicine and Cellular Longevity, 2009
640 citations recorded by the source corpus.
Oxidative stress contributes to the pathophysiology of exposure to heavy metals/metalloid. Beneficial renal effects of some medications, such as chelation therapy depend at least partially on the ability to alleviate oxidative stress. The administration of various natural or synthetic antioxidants has been shown to be of benefit in the prevention and attenuation of metal induced biochemical alterations. These include vitamins, N-acetylcysteine, α-lipoic acid, melatonin, dietary flavonoids and many others. Human studies are limited in this regard. Under certain conditions, surprisingly, the antioxidant supplements may exhibit pro-oxidant properties and even worsen metal induced toxic damage. To date, the evidence is insufficient to recommend antioxidant supplements in subject with exposure to metals. Prospective, controlled clinical trials on safety and effectiveness of different therapeutic antioxidant strategies either individually or in combination with chelating agent are indispensable. The present review focuses on structural, chemical and biological aspects of antioxidants particularly related to their chelating properties.
Subfields: Biochemistry, Nutrition and Dietetics, Organic Chemistry
View Paper: https://www.semanticscholar.org/paper/9c759f1edbe73db1014b38c4d1b8b891349c59ef
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Citations in the corpus
- Heavy Metal Stress and Some Mechanisms of Plant Defense Response (2015, background): “The redox metals can directly generate oxidative injury via undergoing HaberWeiss and Fenton reactions, which leads to the aforementioned production of ROS or oxygen free radicals species in plants, resulting in cell homeostasis disruption, DNA strand breakage, defragmentation of proteins, or cell m”
- Green synthesis of zinc oxide nanoparticles: A review of the synthesis methodology and mechanism of formation (2020, background): “These compounds are more known as antioxidants as they can neutralize reactive oxygen species (ROS) and free radicals and chelate metals (Flora, 2009).”
- A review on antioxidants, prooxidants and related controversy: natural and synthetic compounds, screening and analysis methodologies and future perspectives. (2013, background): “Fe3+ + OH + OH ) forming the hydroxyl radical HO (Flora, 2009).”
- The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state (2015, neutral): “[2, 24].”