Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer

By A. Janowska-Wieczorek, M. Wysoczynski, J. Kijowski, L. Marquez-Curtis, B. Machalinski, J. Ratajczak, M. Ratajczak. International Journal of Cancer, 2005

792 citations recorded by the source corpus.

Subfields: Cancer Research, Hematology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9c6a8c0c4873a5fadf9767a5aa07899fd3145bd1

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Citations in the corpus

Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials. (2012, neutral): “inflammation, and coagulation were reported [45].”
Platelets at the interface of thrombosis, inflammation, and cancer. (2015, background): “Platelets have the ability to delivermultiple proangiogenic factors to the tumor, aswell as the ability to stimulate expression of proangiogenic factors by the tumor cell.(58) Platelets have long been identified as a major source of vascular endothelial growth factor (VEGF),(64,65) platelet-derived ”
Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: a new approach for drug delivery. (2014, background): “MV secretion by cells is usually increased in many pathologies [50–52].”
Routes and mechanisms of extracellular vesicle uptake (2014, background): “of angiogenesis (6), bystander effect (7) and immune”
Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes (2019, background): “Platelet-derived exosomes have been shown to induce tumor chemotaxis, proliferation, invasion, and expression of angiogenic factors and also promote thrombus formation and metastasis [234,235].”
Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy. (2014, positive): “Possible mechanisms of exosome uptake by target cells include specific binding to surface receptors (34, 35), fusion to the plasma membrane (36), or internalization (37).”
Exosome-Based Cell-Cell Communication in the Tumor Microenvironment (2018, background): “Platelet-derived EV were also shown to induce tumor chemotaxis, proliferation, invasion and expression of angiogenic factors, contributing to the formation of distant metastasis (Janowska-Wieczorek et al., 2005, 2006; Toth et al., 2008; Dashevsky et al., 2009).”