Pro-resolving lipid mediators are leads for resolution physiology

By C. Serhan. Nature, 2014

2,778 citations recorded by the source corpus.

Subfields: Biochemistry, Nutrition and Dietetics, Surgery

View Paper: https://www.semanticscholar.org/paper/5da1c5a34d3a730cdb8aa09c4ed9c05aa4e8c289

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Citations in the corpus

Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury (2015, background): “Physiologically, acute neutrophilic inflammation is followed by a resolution phase [176], important for tissue homeostasis.”
Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs. (2015, background): “Protectin D1 is produced via LOX, epoxide formation from the hydroperoxide product, and epoxide hydrolase activity (95) while protectin DX is formed via double LOX activity (96).”
Role of neuroinflammation in neurodegeneration development (2023, background): “LXs, protectins, resolvins and maresins are SPMs generated in human tissues and play critical role in inflammation resolution.(417) Resolution is a highly coordinated process that occurs in response to inflammation to limit tissue damage and promote repair.”
PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals (2017, background): “…19, 2017 ª 2017 Elsevier Inc. INTRODUCTION One of the hallmarks of aerobic life is the enzymatic generation of oxygenated polyunsaturated lipids, free polyunsaturated fatty acids (PUFA), and PUFA esterified into phospholipids (PLs) as their diversity made them valuable for signaling (Serhan, 2014).”
Specialized pro-resolving mediators: endogenous regulators of infection and inflammation (2015, background): “Recently, a new array of molecules that function in the resolution of inflammation were elucidated and named specialized pro-resolving mediators (SPMs) 4, 5 .”
Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators. (2018, background): “The this mini-series Review, we briefly address active endogenous resolution programs and novel resolution mediators as promising terrain for new therapeutic approaches (7) that would serve as immunoresolvents rather than immunosuppressants (14) — namely, pro-resolving agonists that stimulate resolu”
Skin Acute Wound Healing: A Comprehensive Review (2019, background): “Restoring of homeostasis begins with neutrophils releasing microparticles containing proresolving protein annexin A1 and proresolving lipid mediators [78]; apoptotic neutrophils expose phosphatidylserine on the surface designating them for efferocytosis.”
The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis. (2020, background): “…effects of SFAs and n-6 PUFAs, n-3 PUFA can be oxidized to specialized pro-resolving mediators (SPMs), including members of the lipoxin, resolvin, protectin and maresin families, and other oxylipins with potent anti-inflammatory and pro-resolving functions (Dennis and Norris, 2015; Serhan, 2014).”