Somatic mutation in cancer and normal cells

By Iñigo Martincorena, Peter J. Campbell. Science, 2015

1,236 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/9bd9dcb61547b538c434523c4078437586a27ba5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Gad Getz
2. Moritz Gerstung
3. David C. Wedge

In Molecular Biology

1. Süleyman Cenk Sahinalp
2. Florian Markowetz
3. Quaid D. Morris
4. Kevin J. Dawson
5. Gad Getz
6. Rameen Beroukhim
7. Paul C. Boutros
8. Moritz Gerstung

Citations in the corpus

• Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas (2018, neutral): “The consequences of DDR deficiency are becoming better understood through analyses of DDR gene alterations in cancer (Alexandrov et al., 2013; Forbes et al., 2017; Garraway and Lander, 2013; Martincorena and Campbell, 2015).”
• Universal Patterns of Selection in Cancer and Somatic Tissues (2018, neutral): “…will carry an extra complement of driver mutations in addition to neutral (passenger) mutations – it is this recurrence of mutations across cancer patients that has underpinned discoveries of cancer genes from the Philadelphia chromosome to modern genomic studies (Martincorena and Campbell, 2015).”
• The evolutionary history of 2,658 cancers (2017, background): “Early clonal (3,625) Clonal (unspeci ed) (2,746)”
• A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity. (2018, neutral): “Cancers invariably accumulate somatic mutations that, depending on the affected gene(s), can drive cancer progression (Martincorena and Campbell, 2015).”