A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality.

By V. Loo, L. Poirier, Mark A. Miller, M. Oughton, M. Libman, S. Michaud, A. Bourgault, T. Nguyen, Charles Frenette, Mirabelle Kelly and 9 more. New England Journal of Medicine, 2005

1,852 citations recorded by the source corpus.

Subfields: Critical Care and Intensive Care Medicine, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/9b7a4a3b214266f0d82e9a653902ec73d0c02db9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Critical Care and Intensive Care Medicine

1. Victoria J. Fraser
2. J. Bartlett

In Infectious Diseases

1. J. Bartlett
2. J. H. Morse

Citations in the corpus

• Development and Validation of a Clostridium difficile Infection Risk Prediction Model (2011, background): “Despite the breadth and depth of knowledge about risk factors available in the medical literature, healthcare facilities still struggle with outbreaks of CDI and increasing rates of disease.(4-7,9,18-20) Most CDI prevention and control strategies, such as the use of contact precautions and environme”
• Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). (2018, neutral): “e14 • CID 2018:66 (1 April) • McDonald et al certain classes—third-/fourth-generation cephalosporins [99], fluoroquinolones [36, 37, 100], carbapenems [99], and clin-”
• Emergence of Clostridium difficile-associated disease in North America and Europe. (2006, background): “A study conducted in 2004 at 12 hospitals in Quebec included a total of 1703 patients with 1719 episodes of nosocomial CDAD [49].”
• Clostridium difficile infection: new developments in epidemiology and pathogenesis (2009, background): “The changing epidemiology of CDI In 2002, the University of Pittsburgh Medical Center in the United States reported an increase in severe CDI, which signalled the beginning of a continuous rise in the rate of CDI in Canad”
• The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome (2006, background): “This has been illustrated by the recent emergence of the hypervirulent NAP1/027 strain in North American hospitals, resulting in significantly increased mortality rate”
• Treatment with monoclonal antibodies against Clostridium difficile toxins. (2010, neutral): “Presence of BI/NAP1/027 strain at enrollment* Yes 2/25 ( 8 ) 6/19 (32) 24 (1 to 50) 0.06”