Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark.

By Alexander J. Ruthenburg, C. D. Allis, J. Wysocka. Molecules and Cells, 2007

1,189 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/9b7223f5c750e004dc76c2eba3335943510857fd

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Citations in the corpus

DNA methylation: The nuts and bolts of repression (2007, background): “Genes are poised for transcriptional activation by the methylation of H3K4 (histone H3 lysine 4) in a reaction that is catalyzed by a family of H3K4 methyltransferases (Ruthenburg et al., 2007).”
Histone Marks in the 'Driver's Seat': Functional Roles in Steering the Transcription Cycle. (2017, background): “H3K4me3 is written by a variety of methyltransferases, including the mixed lineage leukemia (MLL) and SET domain containing 1A & B (SETD1A/B) complexes (reviewed in [20,21]).”
Epigenetics: A Landscape Takes Shape (2007, background): “Effector proteins recognize specific histone modifications, while presenters are proposed to impart substrate specificity for histone-modifying enzymes (Ruthenburg et al., 2007).”
DNA methylation: superior or subordinate in the epigenetic hierarchy? (2011, background): “In mammals, there are at least 10 known or predicted H3K4 methyltransferases, which are generally categorized into the MLL (mixed lineage leukemia) family, SET1 family, and others.(55) H3K4 methylation may protect certain loci from DNA methylation.”
CpG islands and the regulation of transcription. (2011, neutral): “CGI methylation is, however, 1014 GENES & DEVELOPMENT essential for maintenance of leak-proof X-chromosome inactivation, as inhibition of DNA methylation leads to gene reactivation in a fraction of cells (Sado et al. 2000; Csankovszki et al. 2001).”
Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4. (2007, background): “Our mutational analysis underscores the specificity of the interaction and verifies the importance of several residues conserved between PHD fingers (Ruthenburg et al., 2007).”
Covalent histone modifications: miswritten, misinterpreted, and miserased in human cancers (2010, background): “Jones, D. R. et al. Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kβ.”
How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers (2007, background): “The emerging effector-mediated paradigm posits that histone PTMs are 'read' by protein modules termed effectors, facilitating meaningful downstream events via the recruitment or stabilization of module-associated chromatin-templated machiner”
A double take on bivalent promoters. (2013, background): “The underlying mechanisms have been studied mostly in yeast, but analogous events likely take place during transcription in metazoans as well (for review, see Ruthenburg et al. 2007; Smith and Shilatifard 2010).”