Frequency of bowel movements and the future risk of Parkinson’s disease

By R. Abbott, H. Petrovitch, LonR. White, K. Masaki, C. Tanner, J. Curb, A. Grandinetti, P. Blanchette, J. Popper, G. Ross. Neurology, 2001

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How researchers see this paper

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MDS research criteria for prodromal Parkinson's disease (2015, methodology): “This is based upon two population-based studies.(35,37) - LR(1) 2.”
Parkinson's disease and parkinsonism: neuropathology. (2012, background): “It is of interest that epidemiologic studies indicate that autonomic symptoms may precede clinical PD by more than a decade (Abbott et al. 2001).”
Parkinson's disease: a dual‐hit hypothesis (2007, background): “There is presently only one investigation in support of this, namely the prospective study of bowel habit in elderly patients who took part in the Honolulu Heart Program [64] .”
Epidemiology of Constipation in North America: A Systematic Review (2004, background): “7 at 24 yr of follow-up, with an average onset at 12 yr after the initial assessment (27).”
Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders (2010, neutral): “These may occur early in the motor progression and there is suggestive evidence that some may even occur in the premotor prologue [2, 3, 47, 66, 74].”
Epidemiology of Parkinson’s disease (2017, background): “During the last few years, there has been a considerable interest in prodromal signs of PD. Constipation was early identified as a risk factor of PD (Abbott et al. 2001).”