Human embryonic stem cells express an immunogenic nonhuman sialic acid

By M. J. Martín, Alysson Renato Muotri, Fred H. Gage, A. Varki. Nature Medicine, 2005

962 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9b31d2cc47d74e2644ba74b76138ebcd4b8d8cd3

How researchers see this paper

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In Biomedical Engineering

1. A. Varki

In Molecular Biology

1. A. Varki
2. R. Schauer

Citations in the corpus

• Risk factors in the development of stem cell therapy (2011, neutral): “prion) as well as activation of host immune system by biomolecules [97] (e.”
• Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells (2008, background): “Human ES cells cultured on mouse feeder cells express an immunogenic nonhuman sialic acid on their surfac”
• Sialic acids in human health and disease (2008, positive): “Second, some of the media components used to culture cells (fetal calf serum and many socalled ‘serum substitutes’) contain substantial amounts of Neu5Gc, which gets metabolically incorporated into the therapeutic cells or glycoproteins [27,31].”
• Properties of the amniotic membrane for potential use in tissue engineering. (2008, background): “For example, it has been reported that HESCs cultured with MEF might take up and express Neu5Gc, a nonhuman sialic acid, capable of inducing an immune response in humans (Martin et al., 2005).”