Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells

By Fumitaka Osakada, H. Ikeda, M. Mandai, T. Wataya, Kiichi Watanabe, N. Yoshimura, A. Akaike, Y. Sasai, Masayo Takahashi. Nature Biotechnology, 2008

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Modeling early retinal development with human embryonic and induced pluripotent stem cells (2009, background): “Previously, retinoic acid and taurine had been used to induce differentiation of photoreceptor-like cells (7).”
Self-formation of optic cups and storable stratified neural retina from human ESCs. (2012, background): “…Cell Stem Cell 10, 771–785, June 14, 2012 ª2012 Elsevier Inc. treatment of day-29 NR epithelia with the Notch inhibitor DAPT (Jadhav et al., 2006; Osakada et al., 2008) for 12–14 days dramatically increased the number of Crx::venus+/Recoverin+ photoreceptor cells (40%–78% of NR cells on day…”
Transplantation of human embryonic stem cells derived photoreceptors restores some visual function in Crx deficient mice (2009, positive): “In a relatively short period of time, human ESCs have been shown to be useful for deriving a variety of different differentiated cells and tissues (D’Amour et al., 2006; Kang et al., 2007; Laflamme et al., 2007; Lamba et al., 2006; Osakada et al., 2008; Yang et al., 2008).”