Lethal H5N1 influenza viruses escape host anti-viral cytokine responses

By S. Seo, E. Hoffmann, R. Webster. Nature Medicine, 2002

721 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology

View Paper: https://www.semanticscholar.org/paper/9b2403d3dcd5c4ccfa7c11f7f8bd77616fddc00c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Yi Guan
2. J. Kash
3. J. Peiris
4. M. D. de Jong
5. J. Taubenberger
6. Yoshihiro Kawaoka
7. R. Randall
8. A. Varki

In Immunology

1. R. Randall

Citations in the corpus

• Avian Influenza Virus (H5N1): a Threat to Human Health (2007, background): “Recombinant H1N1 viruses containing the NS gene of 1997 H5N1 viruses were more pathogenic in pigs, possibly by escaping the antiviral effects of interferons and tumor necrosis factor alpha (190).”
• Influenza Virus Evolution, Host Adaptation and Pandemic Formation (2010, background): “reported that increased virulence in pigs of a human H1N1 virus containing the NS gene an H5N1 HPAI required substitution of Asp for Glu at amino acid 92 (Seo et al., 2002), and this mutation has been associated with increased resistance to interferon (Lipatov et al.”
• Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia (2006, background): “Laboratory experiments suggest that virus-induced cytokine dysregulation may contribute to disease severity [6] [7] [8] [9] .”
• Influenza: lessons from past pandemics, warnings from current incidents (2005, background): “Therefore, a recombinant human H1N1 virus that contains the non-structural (NS) gene segment from the 1997 H5N1 virus showed increased pathogenicity in pig”
• The multifunctional NS1 protein of influenza A viruses. (2008, background): “In a mouse model, the NS1 protein of a human H5N1 influenza virus reduced systemic and pulmonary pro-inflammatory cytokines and prevented TNF-a-mediated bone marrow lymphocyte depletion (Hyland et al., 2006).”
• Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia (2004, neutral): “The eight gene segments are (horizontal bars starting at the top downwards): PB2, PB1, PA, HA, NP, NA, M and NS.”