Influenza Virus Evolution, Host Adaptation and Pandemic Formation

By J. Taubenberger, J. Kash. Cell Host and Microbe, 2010

916 citations recorded by the source corpus.

Newly emerging or `re-emerging' viral diseases continue to pose significant global public health threats. Prototypic are influenza viruses that are major causes of human respiratory infections and mortality. Influenza viruses can cause zoonotic infections and adapt to humans leading to sustained transmission and emergence of novel viruses. Mechanisms by which viruses evolve in one host, cause zoonotic infection and adapt to a new host species remain unelucidated. Here we review evolution of influenza A viruses in their reservoir hosts and discuss genetic changes associated with introduction of novel viruses into humans leading to pandemics and the establishment of seasonal viruses.

Subfields: Agronomy and Crop Science, Epidemiology, Modeling and Simulation

View Paper: https://www.semanticscholar.org/paper/95cca81812e6ad8724636631ce8bb4fd07214d69

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Agronomy and Crop Science

1. J. Taubenberger
2. Nicholas C. Wu
3. J. Kash

In Epidemiology

1. Barney S. Graham
2. J. Kash
3. Ren Sun
4. J. Taubenberger
5. Nicholas C. Wu
6. M. Kanekiyo

Citations in the corpus

• An Overlapping Protein-Coding Region in Influenza A Virus Segment 3 Modulates the Host Response (2012, background): “While some aspects of this variability can be explained, IAV pathogenesis remains imperfectly understood and difficult to predict (2).”
• Computational approaches to predict bacteriophage–host relationships (2015, background): “In general, the evolution of virus–host specificity and the related infection mechanisms remain poorly understood, even in clinically important viruses like influenza A that, upon evolving to infect a different host, can cause global epidemics in humans (Taubenberger and Kash 2010).”
• Next-Generation Influenza Vaccines. (2020, background): “This complex multilevel capacity for antigenic diversity and immune escape makes it challenging to design vaccines that will be capable of inducing effective immunity against future unforeseen influenza viruses (Taubenberger and Kash 2010).”
• Systematic Identification of H274Y Compensatory Mutations in Influenza A Virus Neuraminidase by High-Throughput Screening (2012, background): “Influenza A viruses, including the well-known 1918 Spanish influenza virus, cause mortality and significant societal cost globally every year (1).”