Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma

By Miriam Moffatt, M. Kabesch, L. Liang, A. Dixon, D. Strachan, S. Heath, M. Depner, A. von Berg, A. Bufe, E. Rietschel and 14 more. Nature, 2007

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Candidate Causal Regulatory Effects by Integration of Expression QTLs with Complex Trait Genetic Associations (2010, methodology): “Our method confirms prior results in the literature suggestive of disease effects mediated through expression (ORMDL3 for asthma risk [13], C8orf13 locus for lupus risk [20], SLC22A5 for Crohn’s disease [12,21]).”
Genome-wide association studies: what do they teach us about asthma and chronic obstructive pulmonary disease? (2009, background): “The first GWA study on asthma was published in 2007 ( 4 ).”
New IBD genetics: common pathways with other diseases (2011, background): “Variants in the same region of 17q21 encompassing the ORMDL3 gene have been associated with Crohn’s disease,(70) ulcerative colitis,(43) and childhood-onset asthma.(99) Association at this locus has also been described with total white cell count in healthy individuals,(100) and with T1DM.”
Genomic selection: prediction of accuracy and maximisation of long term response (2009, methodology): “estimates as used by Schaeffer (2006). This is probably a very robust method regardless of the true distribution and the accuracy of the genomic EBVs approach 100% if enough data is available.”