PTP1B regulates leptin signal transduction in vivo.

By J. Zabolotny, K. Bence-Hanulec, A. Stricker‐Krongrad, Fawaz G. Haj, Yongping Wang, Y. Minokoshi, Young-Bum Kim, J. Elmquist, L. Tartaglia, B. Kahn and 1 more. Developmental Cell, 2002

819 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Molecular Biology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/9abbab49f5678d02ef112638f183aa2b05a255f4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. B. Kahn
2. J. Oakhill
3. S. Galic
4. G. Steinberg
5. David M. Sabatini
6. M. Laplante
7. G. Boden

In Molecular Biology

1. B. Kahn
2. G. Hotamisligil
3. G. Steinberg

In Nutrition and Dietetics

1. B. Kahn

Citations in the corpus

• Adipose tissue as an endocrine organ. (2010, background): “PTP1B has been shown to negatively regulate hypothalamic leptin signaling by dephosphorylating JAK2, leading to reduced leptin-induced STAT3 phosphorylation (Cheng et al., 2002; Zabolotny et al., 2002).”
• Protein tyrosine phosphatase 1B inhibitors for diabetes (2002, neutral): “cgi?l=20848">Stat3 phosphorylation on peripheral leptin challeng”
• Adipose Tissue in Obesity-Related Inflammation and Insulin Resistance: Cells, Cytokines, and Chemokines (2013, neutral): “Moreover, neuronal deletion as well as whole-body knock-out of protein tyrosine phosphatase 1B (PTP1B) increased leptin and insulin sensitivity, preventing body weight gain in a diet-induced obesity animal model [47, 48], hence suggesting that, likewise SOCS3, PTP1B also orchestrates leptin resistan”
• The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells (2017, background): “PTP1B can negatively affect the regulation of JAK2 and TYK2 but JAK1 is not implicated [98].”
• Neuronal PTP1B regulates body weight, adiposity and leptin action (2006, background): “Previous studies suggested that PTP1B negatively regulates hypothalamic leptin signaling and, consequently, controls adiposity, by dephosphorylating Jak2 (refs”
• The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review (2007, background): “In addition, PTP1B has been suggested to be a valuable target for the treatment of leptin resistance in human obesity (160).”