The hippocampus and mechanisms of declarative memory.

By Howard Eichenbaum. 1999

The hippocampus is critical to declarative memory in humans and spatial memory in rodents. This review attempts to bridge between these two characterizations of hippocampal dependent memory, and in doing so reveal fundamental cognitive and neural coding mechanisms that are common to both. Evidence is presented that the hippocampus and its connections are critical to the establishment of a systematic organization of memories and to flexible expression of memory outside repetition of the training experience. In addition, evidence is presented that hippocampal neurons encode a broad range of experience and that these codings may be organized as representations of episodes in memory. It is suggested that these episodic codings are linked by common elements to construct an organized representation of acquired knowledge.

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Citations in the corpus

Generalization Through the Recurrent Interaction of Episodic Memories (2012, methodology): “We emphasize that REMERGE achieves generalization through a retrieval-based search process, rather than necessitating the formation of explicit representations of the linear hierarchy as argued by alternative accounts (e.g., Eichenbaum, 1999; Howard et al., 2005).”
Stress and Memory: Behavioral Effects and Neurobiological Mechanisms (2007, background): “[30]; Squire and Zola [31]; Verfaellie and Keane [32]; Eichenbaum [33]; Moscovitch et al.”
Relational learning with and without awareness: Transitive inference using nonverbal stimuli in humans (2001, background): “Nondeclarative memory reveals itself in habits, procedural knowledge, perceptual priming, simple sequence learning, single-discriminant forms of classical and operant conditioning, and path-based route learning (for reviews, see Eichenbaum, 1999b; Moscovitch, 2000).”
Hippocampal Microcircuits, Functional Connectivity, and Prostheses (2015, background): “The hippocampal formation is a brain region responsible for the formation of new long-term declarative memories (Squire and Zola-Morgan 1991; Eichenbaum 1999): the “fact-based” or episodic (autobiographical) memories.”
Memory and the brain. (2002, background): “The hippocampus is able to synthesize information from multiple sensory modalities and, in turn, sends connections widely to many parts of the cerebral cortex.(20) Thus, the hippocampal formation is thought to play a critical role in memory by relating different sensory stimuli of a”
The hippocampus and inferential reasoning: building memories to navigate future decisions (2012, background): “Relational memory theory proposes that the hippocampus maintains representations of individual events while also directly encoding relationships between separate experiences (Eichenbaum, 1999).”