Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA

By Wenqiang Yu, D. Gius, P. Onyango, Kristi Muldoon-Jacobs, J. Karp, Andrew P. Feinberg, H. Cui. Nature, 2008

862 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/1db836d51a574aabb97a54733a7962c053f1a354

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In Molecular Biology

Citations in the corpus

Molecular Interplay of the Non-coding RNA ANRIL and Methylated Histone H3 Lysine 27 by Polycomb CBX7 in Transcriptional Silencing of INK4a (2010, positive): “This transcript promotes and maintains the epigenetic state of the CDKN2B (INK4b) gene and is an antisense transcript to INK4b (Yu et al., 2008), and single nucleotide polymorphisms associated with ANRIL have been linked to enhanced risk of atherosclerosis (Broadbent et al.”
A decade of exploring the cancer epigenome — biological and translational implications (2011, background): “Intriguingly, non-coding RNAs and anti-sense RNA sequences have also been linked to the development of cancer-specific DNA hypermethylation at gene promoters, and to the recruitment of silencing complexes, such as PcGs, which may subsequently make these regions vulnerable to DNA methylation change”
Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans (2011, background): “A handful of studies have implicated lncRNAs in a variety of disease states,(10,11) and altered lncRNA levels can result in aberrant expression of gene products that may contribute to cancer biology.(12,13) However, there are only preliminary studies on the role of lncRNAs in HCC,(14,15) and the ove”
Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation. (2008, background): “dently characterized long ncRNAs (Prasanth and Spector 2007) argue that many of these transcripts may be intrinsically functional, especially in view of the findings that at least some of these RNAs may act in trans (Rinn et al. 2007; Yu et al. 2008) and”
Non‐coding RNAs: regulators of disease (2010, background): “A transcript antisense to the p15 tumour suppressor gene, first identified in a human leukaemia, regulates the chromatin and DNA methylation status of the p15 locus [186].”
Non-coding RNAs in human disease (2011, background): “The p15 antisense lncRNA, p15AS , which was first identified in human leukaemia, has also been shown to induce the silencing of the p15 tumour suppressor gene locus by inducing the formation of heterochromati”
Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3′ exons of TACSTD1 (2009, background): “Additionally, it was demonstrated that the p15 tumor suppressor gene can be transcriptionally silenced by antisense p15 RNA via the induction of epigenetic chromatin changes and, eventually, hypermethylation of the p15 promoter predominantly in cis”
Long non-coding RNAs: a new frontier in the study of human diseases. (2013, neutral): “3 Transcription regulation [17–20]”