Proteostasis impairment in protein-misfolding and -aggregation diseases.

By M. Hipp, Sae-Hun Park, F. Hartl. Trends in Cell Biology, 2014

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In vivo aspects of protein folding and quality control (2016, background): “A key role in aggregation prevention and aggregate dissociation is played by the Hsp70 machinery, as shown by overexpressing single or multiple components of the system in cellular and animal disease models (124, 154, 182, 183).”
Pathways of cellular proteostasis in aging and disease (2018, background): “, 2014) or by interference of toxic aggregate species with PN function (Hipp et al., 2014).”