Agouti-related peptide–expressing neurons are mandatory for feeding

By E. Gropp, M. Shanabrough, Erzsébet Borók, Allison W. Xu, R. Janoschek, T. Buch, L. Plum, N. Balthasar, B. Hampel, A. Waisman and 3 more. Nature Neuroscience, 2005

779 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Endocrine and Autonomic Systems, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/99cd8b0541e2c68b08190be45d4bd5b2889c6a4c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

1. E. Maratos-Flier
2. J. Armstrong
3. S. Waddell
4. Bryan L. Roth
5. Linh Vong
6. M. Krashes
7. Bradford B. Lowell

In Endocrine and Autonomic Systems

1. Bryan L. Roth
2. A. N. van den Pol
3. Bradford B. Lowell
4. S. Waddell
5. C. Ye
6. Roger Cone
7. M. Krashes

In Nutrition and Dietetics

1. A. N. van den Pol
2. Bradford B. Lowell
3. Roger Cone
4. Bryan L. Roth

Citations in the corpus

• A neural circuit mechanism integrating motivational state with memory expression in Drosophila (2009, background): “Most impressively, ablation of NPY-expressing neurons from adult mice leads to starvation (Bewick et al., 2005; Gropp et al., 2005; Luquet et al., 2005).”
• Studies on the physiological functions of the melanocortin system. (2006, background): “Targeted destruction of AgRP/neuropeptide Y (NPY) neurons (58, 59) also demonstrates the importance of these neurons for maintenance of body weight.”
• Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons (2011, positive): “, 1997), and the neurons that express them (POMC and AgRP neurons which are located primarily in the arcuate) (Bewick et al., 2005; Gropp et al., 2005; Luquet et al., 2005; Xu et al., 2005), play key roles in regulating body weight.”
• Neuropeptide transmission in brain circuits (2012, background): “However, selective loss of AgRP/NPY neurons in the adult led to a cessation of feeding and death (Luquet et al, 2005; Gropp et al, 2005), suggesting that NPY and AgRP, while important modulators of food intake, are only part of the transmitter puzzle regulating energy homeostasis, and that other…”
• Rapid, reversible activation of AgRP neurons drives feeding behavior in mice. (2011, background): “Conversely, acute ablation of AgRP neurons in adult mice, a manipulation associated with gliosis (5), induces severe hypophagia (7, 8).”