The oxytocin receptor system: structure, function, and regulation.

By G. Gimpl, F. Fahrenholz. Physiological Reviews, 2001

2,972 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Reproductive Medicine, Social Psychology

View Paper: https://www.semanticscholar.org/paper/99a4ea1a61ad0e1283b728167a212595bd44ee68

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In Endocrine and Autonomic Systems

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Citations in the corpus

A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function (2010, background): “The human OXTR gene is located on chromosome 3p25, spans 17 kb, contains four exons and three introns (24), and encodes a 389-aa polypeptide with seven transmembrane domains belonging to the class I G-protein-coupled receptor family (25).”
Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters (2003, background): “OT-R, V1a-R, and V1b-R are all coupled via Gq proteins to PLC to induce PI turnover and Ca 2 i increase, whereas the V2-R is positively coupled to AC (see Birnbaumer, 2000; Gimpl and Fahrenholz, 2001; for reviews).”
Oxytocin and social affiliation in humans. (2012, background): “…of OT on human affiliation, apart from the obvious involvement of OT in the birth of the " mammalian dyad " by initiating uterine contraction and milk letdown, functions that were considered for decades as the sole tasks of this neuropeptide (Gimpl and Fahrenholz, 2001; Insel, 2010; Young, 2009).”
Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans (2009, background): “We examined individual differences at a polymorphic site in the oxytocin receptor (OXTR) gene, which is localized in single copy to chromosome 3 of the human genome (4).”
Oxytocin improves "mind-reading" in humans. (2007, neutral): “Notably, prominent oxytocin receptor binding has been found in respective brain regions, in particular, the hippocampus and the septum (Gimpl and Fahrenholz 2001).”
Oxytocin and the neural mechanisms regulating social cognition and affiliative behavior. (2009, background): “The human OTR gene has a binding site for the inflammatory cytokine nucleofactor interleukin-6 (NF IL-6) and for acutephase response elements, which are induced by infection or inflammation [[94] for review see [93]].”
Psychobiological Mechanisms Underlying the Social Buffering of the HPA Axis: A Review of Animal Models and Human Studies across Development (2013, background): “Furthermore, OT is synthesized peripherally (e.g., in the uterus, placenta, amnion, corpus luteum, testis, and heart; Gimpl & Fahrenholz, 2001).”
Hormonal Regulation of Mammary Differentiation and Milk Secretion (2004, background): “The neurophysiology of oxytocin release has received extensive study as detailed in excellent reviews (93,95).”
Evoked axonal oxytocin release in the central amygdala attenuates fear response. (2012, positive): “OT neurons of the PVN and SON projected to a wide range of OT-R-expressing forebrain structures (Figures 2 and S2; Gimpl and Fahrenholz, 2001), though PVN neurons provided many more prominent projections to more numerous structures (29 of 34 regions analyzed; Figure 2) than SON neurons (five…”
Monetary sacrifice among strangers is mediated by endogenous oxytocin release after physical contact (2008, methodology): “Basal OT levels are highly variable since, like most physiologic systems, tight regulation is unnecessary absent a direct stimulus (Gimpl & Fahrenholz, 2001).”
The Social Salience Hypothesis of Oxytocin. (2016, positive): “binding sites across the mesocorticolimbic DA system (93-96).”
Neuroendocrine pharmacology of stress. (2003, background): “Oxytocin has been suggested to play a role in sodium balance and in a central anxiolytic circuit (Gimpl and Fahrenholz, 2001), while prolactin has been suggested to modulate immune function (Neidhart, 1998).”
Oxytocin: the Great Facilitator of Life (2009, positive): “The Oxtr gene has several other response elements in its promoter, including an interleukin response element, a cAMP response element, and AP-1, AP-2, AP-3, and AP-4 sites (Bale and Dorsa, 1998; Gimpl and Fahrenholz, 2001; Rozen et al., 1995).”