Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans

By S. Rodrigues, Laura R. Saslow, N. García, Oliver P. John, Dacher Keltner. Proceedings of the National Academy of Sciences of the United States of America, 2009

781 citations recorded by the source corpus.

Subfields: Experimental and Cognitive Psychology, Social Psychology

View Paper: https://www.semanticscholar.org/paper/3a81f244bd6e2fe436b3facd51f1eae8b62abbf7

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In Experimental and Cognitive Psychology

In Social Psychology

Citations in the corpus

The Challenge of Translation in Social Neuroscience: A Review of Oxytocin, Vasopressin, and Affiliative Behavior (2010, background): “(Ebstein et al., 2009; Israel et al., 2008; Knafo et al., 2008; Rodrigues et al., 2009; Walum et al., 2008) The human AVP V1a receptor gene is relatively simple, 2 exons and 1 intron, located at 12q14-15 with 3 polymorphisms located in the 5′ flanking region and one in the intron.”
Oxytocin and social affiliation in humans. (2012, background): “Variations in OXTR have been associated with multiple social and emotional processes (Apicella et al., 2010; Israel et al., 2009; Kim et al., 2010; Rodrigues et al., 2009), and risk alleles on the OXTR rs2254298 and rs1042778 SNPs have been associated with increased risk for disorders characterized…”
A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function (2010, background): “In good agreement with our present findings, prior data relates OXTR rs53576A to deficits in empathy (19), attachment (27) and sensitive parenting (26), a behavioral phenotype characterized by reduced maternal awareness of the needs and subtle emotional signals of children.”
Oxytocin Enhances Amygdala-Dependent, Socially Reinforced Learning and Emotional Empathy in Humans (2010, background): “Even though empathy is influenced by OT receptor (OTR) genetic variation (Rodrigues et al., 2009) and closely related to prosocial and bonding behaviors that have been suggested to be enhanced by OT (Zak et al., 2007), there is as yet no direct experimental evidence for a modulation of empathy by…”
Borderline Personality Disorder (2016, neutral): “quality of marital relationships, as well as childhood problems, which renders them interesting candidates for research in BPD [82-85].”
Oxytocin promotes human ethnocentrism (2011, background): “There is no doubt that oxytocin is implicated in the development of trust (10, 18), empathy, and prosociality (11), but these tendencies appear limited to individuals belonging to one’s in-group (16, 17).”
The Social Salience Hypothesis of Oxytocin. (2016, positive): “For example, Kumsta and Heinrichs (46) list in their review studies showing that inOT attenuates neuroendocrine stress reactivity (48), decreases amygdala activation in response to threatening stimuli (49), as well as an association between the OT receptor gene rs53576 and dispositional empathy and ”