Palmitoylation of intracellular signaling proteins: regulation and function.

By J. Smotrys, M. Linder. Annual Review of Biochemistry, 2004

627 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/99972893585af411b5dba1a13fc3a33c5c3db8b5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. M. Resh
2. R. Deschenes
3. M. Linder
4. Toshifumi Takao
5. D. Virshup

In Molecular Biology

1. M. Resh
2. R. Deschenes
3. S. Levy
4. Yu Xue
5. Jonathan Kim
6. O. Clarke
7. Heidi E. Hamm
8. G. Parisi

Citations in the corpus

• Review of octopamine in insect nervous systems (2012, neutral): “165 The thioester bond formed between the palmitate and the cysteine is cleavable, so the palmitoylation state of a receptor can be used to regulate its activity.”
• Palmitoylation: policing protein stability and traffic (2007, background): “We begin with a brief introduction to the structure and mechanism of palmitoylation (for more detail, see Ref”
• Targeting Protein Lipidation in Disease (2012, background): “Regulated cycles of palmitoylation and depalmitoylation lead to reversible membrane association, allowing palmitoylated proteins to signal from multiple subcellular locations [3, 4].”
• Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion. (2006, background): “N-myristoylation refers to the covalent modification with myristate at the N-glycine of proteins, S-palmitoylation refers to the reversible addition of fatty acids to cysteine residues through thioester linkages, and N-palmitoylation, first described for Hedgehog protein, involves modification at th”
• Heterotrimeric G protein activation by G-protein-coupled receptors (2008, background): “These modifications regulate membrane localization and protein–protein interaction”
• Riding the DUBway: regulation of protein trafficking by deubiquitylating enzymes (2006, neutral): “Different cells, when imaged with different oxidant-detection methods, display subcellular restriction of oxidant activity around regions of cytoskeletal rearrangement (Fig.”
• CSS-Palm 2.0: an updated software for palmitoylation sites prediction. (2008, background): “…in protein substrates through thioester linkages (el-Husseini Ael and Bredt, 2002; Bijlmakers and Marsh, 2003; Dietrich and Ungermann, 2004; Smotrys and Linder, 2004; Resh, 2006a, 2006b; Roth et al., 2006; Greaves and Chamberlain, 2007; Linder and Deschenes, 2007; Nadolski and Linder,…”
• The tetraspanin web modulates immune-signalling complexes (2005, background): “S -palmitoylation is essential for the translocation of several signalling molecules to DRM”
• Structural basis of WLS/Evi-mediated Wnt transport and secretion (2020, background): “When Wnt covalent O-acylation was first identified, speculation centered on a membrane-tethering or lipoprotein-binding role for the fatty acid, similar to the role the far more common S-palmitoylation plays in diverse proteins (Panáková et al., 2005; Smotrys and Linder, 2004; Takada et al., 2006; W”
• Thematic review series: Lipid Posttranslational Modifications. Protein palmitoylation by a family of DHHC protein S-acyltransferases Published, JLR Papers in Press, April 1, 2006. (2006, background): “Palmitoylation is also involved in protein trafficking, organelle inheritance, and vesicle fusion (3).”
• Wnt signaling and stem cell control (2008, neutral): “targeting, and protein–protein interactions (Smotrys and Linder 2004; Miura and Treisman 2006).”