Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells.

By C. Imai, S. Iwamoto, Dario Campana. Blood, 2005

639 citations recorded by the source corpus.

Subfields: Hematology, Immunology

View Paper: https://www.semanticscholar.org/paper/997f32400f73eb2a82b0ebe1d30eb5f1a58487c7

How researchers see this paper

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In Immunology

1. R. Flavell
2. Shizuo Akira
3. Alexander Y. Rudensky
4. R. Medzhitov

Citations in the corpus

• CAR-NK cells: A promising cellular immunotherapy for cancer (2020, background): “[84] Furthermore, K562 cells coexpressing both mIL-15 and 4-1BBL stimulated more efficient NK cell expansion, which has been adapted to produce large numbers of clinical-grade NK cells.”
• Chimeric Receptor mRNA Transfection as a Tool to Generate Antineoplastic Lymphocytes (2008, positive): “It has been reported that NK cells transduced with anti-CD19 CIR possessed CD19-specific killing activity (Imai et al. , 2005).”
• Synthetic Messenger RNA as a Tool for Gene Therapy (2006, neutral): “CD8 (cid:2) cytotoxic T lymphocytes (CTLs) as well as natural killer cells toward CD19 (cid:2) targets (Imai et al ., 2004, 2005).”