The extracellular matrix as a scaffold for tissue reconstruction.

By S. Badylak. Seminars in Cell and Developmental Biology, 2002

810 citations recorded by the source corpus.

Subfields: Biomaterials, Hematology, Surgery

View Paper: https://www.semanticscholar.org/paper/9962e51a5f4cc3e428a8c4af0bfbc656f139e95e

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Citations in the corpus

Nanofiber technology: designing the next generation of tissue engineering scaffolds. (2007, background): “There have been investigations into the use of xenogeneic and allogeneic ECM as tissue engineering devices [ 32 ,33]; but the problems associated with this approach include age-related factors, cell lysis, and calcification.”
Bioactive Modification of Poly(ethylene glycol) Hydrogels for Tissue Engineering (2010, background): “ECM componentsplaya crucial instructive role inmediatingcell functions, andpossess critical biological functions like cell adhesion, proteolytic degradation and growth factor binding [48,49].”
Local force and geometry sensing regulate cell functions (2006, background): “Based on observations with laser tweezers, it became clear that changes in force (of ∼10 pN) over a timescale of 1 second or over a length of 50–100 nm (for example, a molecular level) can give rise to rigidity response”
The use of whole organ decellularization for the generation of a vascularized liver organoid (2011, methodology): “A significant advancement in the field of bioscaffold design has been the utilization of decellularized tissue as the three-dimensional scaffold in tissue engineering strategies.(11) Our laboratory has previously reported the successful decellularization of porcine aortas and Abbreviations: CK, cyto”
Extracellular Matrix Hydrogels from Decellularized Tissues: Structure and Function (2016, positive): “cell behavior are not fully understood but likely include release of bound growth factors [27], cytokines, and chemokines [28], presentation of cryptic peptides [29-32], exposure of bioactive motifs, and as recently reported, through bioactive matrix-bound nanovesicles [33].”