Radial glia give rise to adult neural stem cells in the subventricular zone.

By Florian Merkle, A. D. Tramontin, Jose Manuel García-Verdugo, Arturo Alvarez-Buylla. Proceedings of the National Academy of Sciences of the United States of America, 2004

894 citations recorded by the source corpus.

Subfields: Cancer Research, Developmental Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/9962269eeeb44e721cfb3e35dc6f56f5fe1a2ce5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Developmental Neuroscience

In Neurology

Citations in the corpus

Adult neurogenesis and the olfactory system. (2009, background): “These adult stem cells are derived from radial glia (Merkle et al., 2004; Merkle et al., 2007), which function as neural stem cells during embryonic development (Anthony et al., 2004).”
Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh (2009, background): “During brain development, periventricular NSCs have radial glia morphology and express RC2 and BLB”
Late-Stage Neuronal Progenitors in the Retina Are Radial Müller Glia That Function as Retinal Stem Cells (2007, background): “Radial glia also give rise to adult neural stem cells in the mammalian telencephalon (Doetsch, 2003; Merkle et al., 2004).”
Schwann Cells: Development and Role in Nerve Repair. (2015, background): “The broad developmental potential of these early PNS glial cells is reminiscent of early CNS glia, radial glial cells that give rise to neurons, astrocytes, oligodendrocytes, and ependymal cells (Merkle et al. 2004).”
Adult Ependymal Cells Are Postmitotic and Are Derived from Radial Glial Cells during Embryogenesis (2005, methodology): “Because radial glia are the only cells in the P0 VZ that have processes that extend though the injection site, this method selectively labels this population of cells (Tramontin et al., 2003; Merkle et al., 2004).”
Brain tumour stem cells (2006, background): “It has been reported that multipotent CD133 + cells, which show features of radial glia — the progenitors that are known to give rise to both ependymal cells and adult neural stem cells in the postnatal subventricular zon”
Making a tumour's bed: glioblastoma stem cells and the vascular niche (2007, background): “Studies conducted over the past 10 years have identified stem cells with regenerative capacity in the adult mammalian brai”
Lake-front property: a unique germinal niche by the lateral ventricles of the adult brain. (2011, neutral): “Viral targeting of these cells via their radial processes, as well as anatomical studies, have demonstrated that during the next several days of postnatal development, the radial glia located on the walls of the lateral ventricles retract their long RC2-positive distal process, lose RC2 expression, ”
Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball patterned arrays (2021, background): “Likewise, radial glial cells are the source of neuroblasts (Merkle et al., 2004) and both cell types co-localized in brain regions since E11.”
Essential Roles of Notch Signaling in Maintenance of Neural Stem Cells in Developing and Adult Brains (2010, background): “…mostly absent at P0 but are formed in the SVZ later (Gates et al., 1995; Tramontin et al., 2003), suggesting that radial glial cells present at birth become GFAP astrocytes during this postnatal period and that some of the GFAP cells function as adult-type neural stem cells (Merkle et al., 2004).”
The Glial Nature of Embryonic and Adult Neural Stem Cells (2009, methodology): “Direct evidence for the origin of different types of olfactory bulb interneurons from particular sublocations of the postnatal SVZ comes from regional labeling of neonatal RG and adult SVZ B cells (Merkle et al. 2004).”
Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. (2006, methodology): “Other radial glial cells transform into SVZ type B cells that have the structural properties of astrocytes (Merkle et al., 2004).”
Contribution of olfactory neural stem cells to tissue maintenance and regeneration (2007, background): “Notably, studies suggest that the neural stem cell population present in the subventricular zone also show different phenotypic characteristics during development and in adulthoo”