Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signaling

By Gregory E. Miller, E. Chen, A. Fok, H. Walker, A. Lim, Erin F Nicholls, Steve W. Cole, Michael S. Kobor. Proceedings of the National Academy of Sciences of the United States of America, 2009

754 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Pediatrics, Perinatology and Child Health, Physiology

View Paper: https://www.semanticscholar.org/paper/47cc8b81960fc7422ec30903eb202cc8f3c9f2ed

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In Behavioral Neuroscience

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Citations in the corpus

From Stress to Inflammation and Major Depressive Disorder: A Social Signal Transduction Theory of Depression (2014, background): “To our knowledge, however, no studies to date have tested for differences in the leukocyte basal transcriptome of depressed versus nondepressed individuals (for related work, see S. W. Cole, 2009, 2010; Fredrickson et al., 2013; A. H. Miller et al., 2009; Pace & Miller, 2009).”
Adverse childhood experiences, allostasis, allostatic load, and age-related disease. (2012, background): “Seventh, to clarify the molecular mechanisms converting psychosocial stress exposure in childhood in biological risk for disease, future research should broaden the emerging evidence relating adverse childhood experiences to changes in epigenetic states and gene expression [170,171].”
Instrumental Variable Estimation of the Causal Effect of Hunger Early in Life on Health Later in Life (2016, background): “Over time, this takes an allostatic toll on the body, resulting in a higher risk of chronic diseases later in life (Zhang et al., 2006; Miller et al., 2009; Morozink et al., 2010; Miller and Chen, 2010; Cole et al., 2011), notably cardiovascular diseases, diabetes and hypertension.”
The behavioral immune system: Current concerns and future directions (2018, background): “Consistent with this idea, a growing body of research finds evidence for increased investment in inflammatory activity among those from unpredictable early life environments (Miller et al., 2009; Miller, Chen, & Parker, 2011).”
Psychological Perspectives on Pathways Linking Socioeconomic Status and Physical Health (2011, background): “…of healthy adults matched on current SES who came from high- versus low-SES families of origin revealed that early-life low SES was associated with resistance to glucocorticoid signaling, which in turn facilitated exaggerated adrenocortical and inflammatory responses (Miller et al. 2009).”
How social class shapes thoughts and actions in organizations (2011, methodology): “Childhood social class leaves a biological residue that has long-term consequences (Miller et al., 2009), and it may similarly leave a cognitive residue that explains variations in the decisions of organization members.”