Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer.

By W. Samowitz, H. Albertsen, Jennifer S. Herrick, T. Levin, C. Sweeney, M. Murtaugh, R. Wolff, M. Slattery. Gastroenterology, 2005

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Serrated Lesions of the Colorectum: Review and Recommendations From an Expert Panel (2012, background): “Clinical associations with CIMP-high CRCs include older age, female sex, and proximal tumor location (31).”
Classification of colorectal cancer based on correlation of clinical, morphological and molecular features (2007, result): “When the same population-based set of cases was studied with respect to CIMP and family history, the link was less strong.(66) However, this analysis employed a cutoff for CIMP in which only about one-third of ‘CIMPpositive’ CRCs had BRAF mutation.”
CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer (2006, background): “In subsequent studies, the CIMP trait was found to be associated with a variety of clinical, histopathological and epidemiological characteristic”
Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours (2013, background): “Other gene expression-based analysis described three groups of CRC patients [23], which correlated with two of the known molecularly defined groups, namely the MSI (renamed CCS2) and the CIN (CCS1) groups, whereas the third group corresponded partly with the CIMP group (CCS3).”
CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer (2008, background): “[9,16–19]”