Leukemia Proto-Oncoprotein MLL Forms a SET1-Like Histone Methyltransferase Complex with Menin To Regulate Hox Gene Expression

By A. Yokoyama, Zhong Wang, J. Wysocka, M. Sanyal, Deborah J. Aufiero, I. Kitabayashi, W. Herr, M. Cleary. Molecular and Cellular Biology, 2004

689 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/4c525e2f30b4e9da02ad2c091943e73827142146

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Citations in the corpus

The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis. (2005, background): “…et al., 2002), a mark that is generally associated with transcriptionally active states of chromatin (Noma et al., 2001; Strahl et al., 1999), thus providing a molecular basis for the characteristic role of MLL in maintenance, not initiation, of embryonic Hox gene expression (Yu et al., 1998).”
The interplay of histone modifications – writers that read (2015, neutral): “Additionally, the recruitment of SETD1 and MLL to specific target genes is mediated by many cell type-specific transcription factors or transcriptional coactivators [19 – 23].”
Wnt signaling: is the party in the nucleus? (2006, background): “The mammalian SET1-related HMT proteins form complexes with Ash2, menin, HCF, WRD5, and RbBP5, and are thought to be frequent direct targets of transcriptional regulators (Yokoyama et al. 2004; Dou et al. 2005; Wysocka et al. 2005b).”
Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (2005, background): “These results extend a previous study, involving different assays, which suggested that WDR5 and RbBP5 interactions with MLL1 are dependent on (but not necessarily restricted to) the SET domain (Yokoyama et al., 2004).”
Multiple endocrine neoplasia type 1 (MEN1): analysis of 1336 mutations reported in the first decade following identification of the gene (2008, background): “Menin, as a component of this MLL complex, regulates the expression of genes such as the Hox homeobox genes [Yokoyama et al., 2004] and the genes for cyclindependent kinase inhibitors, p27 and p18 [Karnik et al., 2005; Milne et al., 2005].”
How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers (2007, background): “The WD40-repeat protein WDR5 is a common component of SET1-family histone methyltransferase complexe”