Nano-C60 cytotoxicity is due to lipid peroxidation.

By Christie M. Sayes, A. Gobin, K. Ausman, Joe S Mendez, Jennifer L. West, V. Colvin. Biomaterials, 2005

670 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Developmental Neuroscience, Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/983a447107d18ba6fc306fbcd48902ee49b41661

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In Biomedical Engineering

In Developmental Neuroscience

In Organic Chemistry

Citations in the corpus

Categorization framework to aid hazard identification of nanomaterials (2007, background): “The studied materials have mainly been nanoparticles suspended in water belonging to category IIIb in Figure 1 (Oberdörster 2004; Sayes et al. 2005), but also some studies with airborne nanoparticles (category IIIc in Figure 1) have been carried out (Baggs et al.”
Electron microscopy of gold nanoparticle intake in the gut of Daphnia magna (2008, background): “While the health effects of nanoparticles exposure are beginning to be addressed in the laboratory at the cellular (Sayes et al. 2005; Magrez et al. 2006) and organ level (Papageorgiou et al. 2007), there remains a question as to the degree to which each organ and cell type will be exposed to these…”
Correlating nanoscale titania structure with toxicity: a cytotoxicity and inflammatory response study with human dermal fibroblasts and human lung epithelial cells. (2006, background): “We note that the doses required to observe changes in cell function, 1500 lg/ml, are relatively large compared to similar studies of carbon nanoparticles, which found altered cell function at much lower doses (0.02 lg/ml) (Sayes et al., 2004, 2005).”
Antimicrobial nanomaterials for water disinfection and microbial control: potential applications and implications. (2008, background): “Studies observing nC60 cytotoxicity in eukaryotic systems have attributed the toxicity to ROS production (Oberdorster, 2004; Sayes et al., 2005; Isakovic et al., 2006; Markovic et al., 2007).”
Toxicity of Metal Oxide Nanoparticles in Mammalian Cells (2006, background): “[11] suggested that mitochondrial membrane disruption due to altered membrane potential contributes to release of the apoptic factor cytochrome C.[12] Thus, shutdown of mitochondrial function under conditions of oxidative stress may induce apoptosis at exposure concentrations that do not lead direct”
Toxicity of single walled carbon nanotubes to rainbow trout, (Oncorhynchus mykiss): respiratory toxicity, organ pathologies, and other physiological effects. (2007, background): “Oxidative stress is a concern because mammalian studies have demonstrated lipid peroxidation during carbon nanoparticle exposure (Shvedova et al., 2003; Sayes et al., 2005 ), and free radical generation is implicated in the accumulation of macrophages and immune responses in tissue damaged by carbo”
Drug delivery and nanoparticles: Applications and hazards (2008, background): “In the past few years a number of papers have described the toxicology of newly engineered nanomaterials, including fullerenes (Sayes et al 2005), carbon nanotubes (Donaldson et al 2006), quantum dots (Hardman 2006) and have illustrated that apart from size and surface area, many more parameters…”