Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes.

By B. Goodpaster, Jing He, Simon C. Watkins, D. Kelley. Journal of Clinical Endocrinology and Metabolism, 2001

1,145 citations recorded by the source corpus.

Subfields: Cell Biology, Physiology, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/982d94ac90458eb39fb2850e327ec116853c38d2

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Citations in the corpus

The Mediterranean diet improves hepatic steatosis and insulin sensitivity in individuals with non-alcoholic fatty liver disease. (2013, methodology): “The LF/HCD,was based on the both the Australian National Heart Foundation Diet (30), and the American Heart Association Diet (23) and the exact diet used is detailed in Appendix 1.”
Integrating Mechanisms for Insulin Resistance: Common Threads and Missing Links (2012, positive): “…accumulate muscle triglyceride but are protected from lipid-induced muscle insulin resistance (Liu et al., 2007) and recapitulate the athlete’s paradox in which endurance athletes have increased muscle triglyceride yet are insulin sensitive (Goodpaster et al., 2001; Krssak et al., 2000).”
A Comprehensive Review on Metabolic Syndrome (2014, background): “CRP. Elevated levels of CRP are associated with an increased WC [46], insulin resistance [47], BMI [48], and hyperglycemia [46] and are increased with the number of the MetS components.”
Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training (2013, positive): “The notion of the lipid paradox is well supported and suggests that other factors independent of TG, such as accumulation of more bioactive lipid species, including DAG or ceramide, and peroxidation of lipid bilayers promote inflammation and are the true culprits of insulin resistance (165, 226, 556”
Adipose Tissue Dysfunction as Determinant of Obesity-Associated Metabolic Complications (2019, background): “However, insulin-sensitive and endurance-trained athletes have also increased lipid content in the skeletal muscle, coexisting with an increased oxidative capacity and lipid metabolism [159,160].”
Physical activity/exercise and type 2 diabetes. (2004, background): “Compared with sedentary control subjects, athletes with high aerobic fitness have increased intramuscular lipids, but are more insulin sensitive, not less (91).”
Obesity and risk of type 2 diabetes and cardiovascular disease in children and adolescents. (2003, background): “Studies in adult and animal models show that lipid accumulation in muscle is correlated with insulin resistance (51, 52).”