Early-Life Blockade of the 5-HT Transporter Alters Emotional Behavior in Adult Mice

By M. Ansorge, Mingming Zhou, A. Lira, R. Hen, J. Gingrich. Science, 2004

840 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Social Psychology

View Paper: https://www.semanticscholar.org/paper/980f7d838bdc1b44a52f7994c1e14931957141f7

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In Cellular and Molecular Neuroscience

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Citations in the corpus

SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation (2011, background): “At the behavioral level, SERT-KO mice are characterized by increased anxietyand stress-related behaviors, as supported, for example, by reduced exploratory behavior in the elevated-plus maze test (Holmes et al., 2003a,b; Ansorge et al., 2004).”
Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder. (2008, positive): “Work from animal models indicates that the developmental timing of alterations to the amygdala–prefrontal cortex circuit greatly affects anxiety-related behavior.(44,45) Turning to humans, the question is how do neural disturbances relate to the onset of anxiety during development.”
Bonsai Trees in Your Head: How the Pavlovian System Sculpts Goal-Directed Choices by Pruning Decision Trees (2012, background): “Dayan and Huys [17] explained this paradox by suggesting that people who experienced high levels of serotonin and thus exaggerated Pavlovian behavioural inhibition during early development [32] would be most sensitive to the effects of any interference with this inhibition in adulthood secondary to ”
5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression (2005, background): “Furthermore, serotonin (5-HT) appears to be critical for the development of emotional circuitry in the brain, and even transient alterations in 5-HT homeostasis during early development modify neural connections implicated in mood disorders and cause permanent elevations in anxiety-related behaviors”