Reduced Expression of the let-7 MicroRNAs in Human Lung Cancers in Association with Shortened Postoperative Survival

By J. Takamizawa, H. Konishi, K. Yanagisawa, S. Tomida, H. Osada, H. Endoh, T. Harano, Yasushi Yatabe, M. Nagino, Y. Nimura and 2 more. Cancer Research, 2004

2,552 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/97c4ead52f67e84d6ab55bb4f73a192533a95e1a

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Citations in the corpus

MicroRNA signature predicts survival and relapse in lung cancer. (2008, background): “In contrast, the reproducibility of hybridization-based microarray technologies is still questionable, and frozen fresh tissues are usually needed in the assay (Jiang et al., 2005; Lu et al., 2005; Tang et al., 2006).”
MicroRNAs in human cancer. (2013, background): “Expression of let-7 is downregulated in non-small cell lung cancer patients [ 192 ] and is associated with poor prognosis [ 125, 193 ] , whereas a miRNA signature was identi fi ed to be associated with prognosis in CLL [ 188 ] .”
Oncomirs — microRNAs with a role in cancer (2006, background): “Interestingly, the mammalian homologues of lin-4 and let-7 have been shown to control cell proliferation in human cell line”
MicroRNA (miRNA) in cancer (2015, background): “The involvement and the role played by miRNAs in many types of cancers were re-ported in different types of cancers, including breast, colon, gastric, lung, prostate and thyroid [20-24].”
OncomiRs: the discovery and progress of microRNAs in cancers (2007, background): “Their study reported the potential clinical and biological effects of let-7 miRNA alteration [50].”
Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma. (2007, background): “Among these, the let-7 family was shown to be down-regulated in various human cancers (22, 30, 31), mir-221 was up-regulated in thyroid carcinomas and glioblastomas (29, 33), and mir-145 was found down-regulated in colon and breast cancers (20, 34–36).”
MicroRNAs in body fluids—the mix of hormones and biomarkers (2011, positive): “In a study of 143 lung cancer samples from patients who underwent potentially curative resection, patients could be classified into two major groups according to let-7 expression, with reduced let-7 expression associated with significantly shorter survival after resection”
MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death (2008, background): “Let-7 is downregulated in a number of human cancers such as lung, colon, or ovarian cancer, and it serves as a prognostic marker for disease outcome (Takamizawa et al., 2004; Johnson et al., 2005; Akao et al., 2006; Yanaihara et al., 2006; Shell et al., 2007).”