Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice

By R. Lee, Min-Jeong Seo, R. Reger, Jeffrey L Spees, A. Pulin, Scott D. Olson, D. Prockop. Proceedings of the National Academy of Sciences of the United States of America, 2006

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Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung (2009, background): “Recent studies have suggested that bone marrow-derived multipotent mesenchymal stem cells (MSCs) may have therapeutic applications in several clinical disorders including myocardial infarction (17), diabetes (18), sepsis (19), hepatic (20), and acute renal failure (21).”
Mechanisms of mesenchymal stem/stromal cell function (2016, background): “ing [101], improved treatment of diabetes [102], enhancement of bone repair [103, 104], and effect(s) on cancer [105].”
Mesenchymal stem cells in health and disease (2008, background): “For example, in an experimental mouse model of diabetes induced by streptozotocin, it was observed that MSCs promoted the endogenous repair of pancreatic islets and renal glomerul”
Mesenchymal stem cells: mechanisms of inflammation. (2011, background): “Several studies have documented the dramatic clinical improvements observed in animal models by using systemically introduced xenogeneic hMSCs rather than allogeneic MSCs as a therapy in mouse models of multiple sclerosis and amyotrophic lateral sclerosis (65), inflammatory bowel disease, infarct, s”