HIF-1 and mechanisms of hypoxia sensing.

By G. Semenza. Current Opinion in Cell Biology, 2001

1,248 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Physiology

View Paper: https://www.semanticscholar.org/paper/973f69929b1ced70a855079385b6a73c28c7de30

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. P. Thomas
2. Lawrence T. Reiter
3. Erinn B. Rankin
4. R. Abraham
5. Georgina N. Masoud
6. Wei Li
7. Md Saydur Rahman
8. Amato J. Giaccia

In Genetics

1. P. Thomas
2. Lawrence T. Reiter
3. Erinn B. Rankin
4. R. Abraham
5. Georgina N. Masoud
6. Wei Li
7. Md Saydur Rahman
8. Amato J. Giaccia

In Physiology

1. P. Thomas
2. Lawrence T. Reiter
3. Erinn B. Rankin
4. Georgina N. Masoud
5. Wei Li
6. Md Saydur Rahman
7. Amato J. Giaccia
8. S. Doronkin

Citations in the corpus

• Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. (2004, neutral): “14).”
• The role of hypoxia-inducible factors in tumorigenesis (2008, background): “and metabolism, angiogenesis, erythropoiesis, cell proliferation, and apoptosis.(1) They are members of the PAS (PERARNT (arylhydrocarbon receptor nuclear translocator)-SIM)”
• Drosophila orthologues to human disease genes: an update on progress. (2008, background): “Although little is known about the mechanisms that elicit the rapid metabolic turnover upon sudden reduction of oxygen supply, some evidence suggests the contribution of processes that trigger a rapid switch to energy conservation upon abrupt imposing of severe hypoxia [reviewed in (105, 106)].”
• Biomarkers of hypoxia exposure and reproductive function in Atlantic croaker: a review with some preliminary findings from the northern Gulf of Mexico hypoxic zone. (2009, background): “…the expression of a wide variety of genes involved in adaptation to low oxygen levels including genes involved in erythropoiesis, angiogenesis, oxygen delivery, apoptosis and glycolysis (Wenger and Gassmann, 1999; Semenza, 2001; Bruick and McKnight, 2002; Nikinmaa, 2002; Nikinmaa and Ress, 2005).”
• Cloning of hif-1α and hif-2α and mRNA expression pattern during development in zebrafish (2007, background): “Target genes include the vascular endothelial growth factor (VEGF), which is involved in angiogenesis; erythropoietin (Semenza, 1999) that promotes red blood cell diVerentiation, and most glycolitic genes (Bruick, 2003; Semenza, 2001 ).”
• Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin (2002, background): “The level of HIF-1-dependent transcriptional activity is limited by the expression of the HIF-1 subunit, which is subject to rapid proteasomal degradation in normoxic cells ( 40 ).”
• HIF-1α pathway: role, regulation and intervention for cancer therapy (2015, background): “SCH66336 (11), a farnesyltransferase derivative demonstrating antitumor activity against non-small-cell lung cancer, inhibits the interaction between HIF-1α and Hsp90 promoting HIF-1α proteasomal degradation(66).”