Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2

By M. Higuchi, S. Maas, F. Single, Jochen C. Hartner, A. Rozov, N. Burnashev, D. Feldmeyer, R. Sprengel, P. Seeburg. Nature, 2000

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Widespread A-to-I RNA Editing of Alu-Containing mRNAs in the Human Transcriptome (2004, background): “of Alu-Containing mRNAs in the Human Transcriptome”
Modulation of microRNA processing and expression through RNA editing by ADAR deaminases (2006, methodology): “Therefore, we examined RNA samples extracted from spleens and thymuses of ADAR1 null mice ( ADAR1 flox/flox :CD19-Cre + ) and ADAR2 null mic”
Functions and Regulation of RNA Editing by ADAR Deaminases (2010, background): “However, ADAR2−/− mice can be rescued by introducing the genomic GluR-BR mutation, which restores expression of GluR-B “edited” at the Q/R site (82).”
Circular RNAs: analysis, expression and potential functions (2016, background): “ADAR is essential for mammalian development: ADAR knockout is embryonic or perinatal lethal, depending on the isoform that is absent (Higuchi et al., 2000; Wang et al., 2000).”
Editing modifies the GABAA receptor subunit α3 (2007, background): “These enzymes differ somewhat in their specificity, but both are essential (Higuchi et al. 2000; Hartner et al. 2004; Wang et al. 2004).”