Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors.

By D. Bilder, Min Li, Norbert Perrimon. Science, 2000

978 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/96aa76bc4f744edaf044af1f096721b51122ab1c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. C. Gottardi
2. Jarema Malicki
3. J. Brugge
4. Jayanta Debnath
5. F. Mantovani
6. Xiangyun Wei
7. L. Banks
8. J. Erler

In Molecular Biology

1. T. Cox
2. C. Gottardi
3. Jarema Malicki
4. J. Brugge
5. Jayanta Debnath
6. F. Mantovani
7. Xiangyun Wei
8. Angela Jeanes

Citations in the corpus

• Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer (2011, background): “…many years it was thought that loss of apicobasal polarity caused by BM disruption was a secondary consequence of oncogenic transformation, later investigations of Drosophilamutants have shown that the loss of polarity determinants might in fact be a driver of tumorigenesis (Bilder et al., 2000).”
• PDZ Domain Proteins: Plug and Play! (2003, background): “Located in the more basal regions of polarized epithelial cells (associated with septate junctions and baso-lateral membranes) lies the Dlg (discs large)-Lgl (lethal giant larvae)-Scribble protein complex, which is also required for the development of epithelial polarity ( 67 ).”
• Modelling glandular epithelial cancers in three-dimensional cultures (2005, background): “In Drosophila melanogaster , disruptions of genes that control polarity, such as scribble ( Scrib ), discs large ( Dlg ) and lethal giant larvae ( Lgl ) elicit hyperplastic growth; therefore, the proper regulation of epithelial polarity may directly influence tumor progressio”
• nagie oko, encoding a MAGUK-family protein, is essential for cellular patterning of the retina (2002, background): “The prototypical member of this family, discs large ( dlg1 ), is essential to the polarity of several fruitfly epitheli”
• Cadherins and cancer: how does cadherin dysfunction promote tumor progression? (2008, background): “, 1998; Petronczki and Knoblich, 2001) and the Scribble/Discs large/Lethal giant larvae complex (Scrib/Dlg/Lgl) is found at the lateral membrane (Bilder et al., 2000).”
• The Human Papillomavirus E6 protein and its contribution to malignant progression (2001, positive): “…tumour suppressor Scrib, which cooperates with Dlg and Lgl to control both formation of cell junctions and inhibition of epithelial cell growth, possibly through controlling the localization of growth factor receptors and signalling molecules (Bilder and Perrimon, 2000; Bilder et al., 2000).”
• Renal defects associated with improper polarization of the CRB and DLG polarity complexes in MALS-3 knockout mice (2007, neutral): “DLG genetically interacts with the multiPDZ protein SCRIB and the WD40 motif protein LGL (Bilder et al., 2000).”
• The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. (2002, background): “Whether luminal apoptosis within oncogene-expressing structures represents an intrinsic studies in Drosophila have shown that disruption of genes controlling cell polarity, including Dlg, Scrib, and clearance mechanism in proliferating structures or a manifestation of proapoptotic pathways activated”