Transcriptome-wide noise controls lineage choice in mammalian progenitor cells

By Hannah H. Chang, Martin Hemberg, Mauricio Barahona, Donald E. Ingber, Sui Huang. Nature, 2008

1,121 citations recorded by the source corpus.

Subfields: Biophysics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/96a0172d480ead4f1f81340d6e8e530b892e0ef8

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Citations in the corpus

Epigenetic reprogramming and induced pluripotency (2009, background): “…of clonally derived hematopoietic progenitor cells have been found to exhibit metastable states (which persist over multiple cell divisions), together with global changes in gene expression and different tendencies to give rise to the erythroid or myeloid lineages (Chang et al., 2008).”
Cellular heterogeneity: when do differences make a difference? (2010, background): “Recently, subpopulations of clonally derived hematopoietic progenitor cells with low or high expression of the stem cell marker Sca-1 were observed to be in dramatically different transcriptional states and to give rise Cell to different blood cell lineages (Chang et al., 2008).”
Cellular Decision-Making and Biological Noise: From Microbes to Mammals (2011, background): “One of the first studies to address this question focused on adult progenitor cells (a multipotent hematopoietic stem cell line) (Chang et al., 2008), observing that the expression of the stem cell marker Sca-1 varied over three orders of magnitude across this cell population.”
Cancer stem cells in glioblastoma (2015, background): “…CSCs from their progenyarederived, in part, fromthe limited recognition of points of relative stability (“attractor states”) in the landscapeof cellular identity that define the stemcell state and transitions into (dedifferentiation) and out of (differentiation) a stable state (Chang et al. 2008).”
Stochastic gene expression and its consequences (2008, background): “To link this stochastic differentiation to variations in gene expression, Chang et al. (2008) showed that variability in the expression of the stem cell marker Sca-1 in individual cells correlated strongly with the probability of that cell to choose an erythroid or myeloid lineage.”
Single-cell RNA-seq: advances and future challenges (2014, positive): “…either due to deterministic reasons because it is part of an activated cellular process or due to random different levels of expression between cells, a phenomenon also called transcriptional noise that cannot be considered insignificant since it has broad implications in cell fate decisions (41).”
Cancer stem cells in solid tumours: accumulating evidence and unresolved questions (2008, background): “Intriguingly, clonal heterogeneity (based on cell surface markers) in a haematopoietic progenitor cell line could be re-established from multiple subclone”