Bone regeneration: current concepts and future directions
By R. Dimitriou, E. Jones, D. Mcgonagle, P. Giannoudis. BMC Medicine, 2011
1,843 citations recorded by the source corpus.
Bone regeneration is a complex, well-orchestrated physiological process of bone formation, which can be seen during normal fracture healing, and is involved in continuous remodelling throughout adult life. However, there are complex clinical conditions in which bone regeneration is required in large quantity, such as for skeletal reconstruction of large bone defects created by trauma, infection, tumour resection and skeletal abnormalities, or cases in which the regenerative process is compromised, including avascular necrosis, atrophic non-unions and osteoporosis. Currently, there is a plethora of different strategies to augment the impaired or 'insufficient' bone-regeneration process, including the 'gold standard' autologous bone graft, free fibula vascularised graft, allograft implantation, and use of growth factors, osteoconductive scaffolds, osteoprogenitor cells and distraction osteogenesis. Improved 'local' strategies in terms of tissue engineering and gene therapy, or even 'systemic' enhancement of bone repair, are under intense investigation, in an effort to overcome the limitations of the current methods, to produce bone-graft substitutes with biomechanical properties that are as identical to normal bone as possible, to accelerate the overall regeneration process, or even to address systemic conditions, such as skeletal disorders and osteoporosis.
Subfields: Biomedical Engineering, Epidemiology, Surgery
View Paper: https://www.semanticscholar.org/paper/e3884ebaac0a11eda0218e7032ce861026ef51d9
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Citations in the corpus
- Bone grafts and biomaterials substitutes for bone defect repair: A review (2017, background): “Bone grafting is one of the most commonly used surgical methods to augment bone regeneration in orthopaedic procedures [3].”
- Bone regenerative medicine: classic options, novel strategies, and future directions (2014, background): “the limitations of autografts in such situations [2,10,13].”
- Bone Tissue Engineering: Recent Advances and Challenges (2012, neutral): “, lead), and (5) maintain the homeo-stasis of key electrolytes via calcium and phosphate ion storage.”
- An Overview of Poly(lactic-co-glycolic) Acid (PLGA)-Based Biomaterials for Bone Tissue Engineering (2014, background): “Bone tissue engineering is a research field with many clinical applications, such as bone replacement in the case of orthopaedic defects, bone neoplasia and tumours, pseudoarthrosis treatment, stabilization of spinal segments, as well as in maxillofacial, craniofacial, orthopaedic, reconstructive, t”
- Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective (2013, positive): “…It provides a scaffold for the ingrowth of cells necessary for bone regeneration (=osteoconductive); it promotes the proliferation of stem cells and their differentiation into osteogenic cells (=osteoinductive) and it holds viable cells that can form new bone tissue (= osteogenic) (22, 47).”