POLYMERIC SCAFFOLDS IN TISSUE ENGINEERING APPLICATION: A REVIEW

By Brahatheeswaran Dhandayuthapani, Y. Yoshida, T. Maekawa, D. Kumar. 2011

1,668 citations recorded by the source corpus.

Current strategies of regenerative medicine are focused on the restoration of pathologically altered tissue architectures by transplantation of cells in combination with supportive scaffolds and biomolecules. In recent years, considerable interest has been given to biologically active scaffolds which are based on similar analogs of the extracellular matrix that have induced synthesis of tissues and organs. To restore function or regenerate tissue, a scaffold is necessary that will act as a temporary matrix for cell proliferation and extracellular matrix deposition, with subsequent ingrowth until the tissues are totally restored or regenerated. Scaffolds have been used for tissue engineering such as bone, cartilage, ligament, skin, vascular tissues, neural tissues, and skeletal muscle and as vehicle for the controlled delivery of drugs, proteins, and DNA. Various technologies come together to construct porous scaffolds to regenerate the tissues/organs and also for controlled and targeted release of bioactive agents in tissue engineering applications. In this paper, an overview of the different types of scaffolds with their material properties is discussed. The fabrication technologies for tissue engineering scaffolds, including the basic and conventional techniques to the more recent ones, are tabulated.

Subfields: Biomaterials, Biomedical Engineering, Surgery

View Paper: https://www.semanticscholar.org/paper/99aeddd60fcf4b7cdaa191d22d91069b904f594a

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In Biomaterials

1. Elbay Malikmammadov
2. T. E. Tanir
3. V. Hasırcı
4. M. Chavali
5. A. Kiziltay
6. N. Hasırcı
7. P. Gentile
8. V. Chiono

In Biomedical Engineering

1. R. Singh
2. J. Knowles
3. M. AlQaysi
4. F. Foroutan
5. M. Chavali
6. Chinmaya Mahapatra
7. Gareth J. Owens
8. H. Kim

In Surgery

1. R. Singh
2. J. Knowles
3. M. AlQaysi
4. F. Foroutan
5. Chinmaya Mahapatra
6. Gareth J. Owens
7. H. Kim
8. Cheol-Min Han

Citations in the corpus

• PCL and PCL-based materials in biomedical applications (2018, background): “structure resembles to that of natural bone and promotes osteoinduction, osteoconduction and osseointegration activities by serving as mineral reservoir which induces new bone formation [123,124].”
• Review of Multifarious Applications of Poly (Lactic Acid) (2016, background): “lost by different pathological conditions, either by developing biological substitutes or by reconstructing tissues([100]).”
• Bone regenerative medicine: classic options, novel strategies, and future directions (2014, background): “A pore size of 200–350 μm is optimal for bone ingrowth and facilitates osteoconduction [71].”
• An Overview of Poly(lactic-co-glycolic) Acid (PLGA)-Based Biomaterials for Bone Tissue Engineering (2014, background): “However, a number of advantages are reported for synthetic polymers as compared with natural polymers, including the highly controlled and consistent degradation properties and excellent reproducible mechanical and physical properties such as tensile strength, elastic modulus and degradation rate [9”
• Recent advances in biomaterials for 3D scaffolds: A review (2019, background): “immune response and better cell interactions while synthetic polymers are cheaper, stronger, and have better functionality although sometimes triggering immune response and toxicity [37].”
• Sol-gel based materials for biomedical applications (2016, background): “Natural polymers are considered as the first biodegradable biomaterials, while synthetic biodegradable polymers can be produced under controlled conditions [474,476].”