Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan

By S. Girardin, I. Boneca, L. Carneiro, A. Antignac, M. Jéhanno, J. Viala, K. Tedin, M. Taha, A. Labigne, Ulrich Zäthringer and 5 more. Science, 2003

1,668 citations recorded by the source corpus.

Subfields: Endocrinology, Immunology, Microbiology

View Paper: https://www.semanticscholar.org/paper/961d8490c84a6d064a17322af658ed2209d0fdac

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology

1. Shizuo Akira
2. G. Núñez
3. P. Sansonetti
4. O. Takeuchi
5. B. B. Finlay
6. Michael A. Fischbach
7. Mohamed S. Donia
8. N. Inohara

In Immunology

1. Shizuo Akira
2. O. Takeuchi
3. Satoshi Uematsu
4. K. Takeda
5. T. Mogensen
6. R. Medzhitov
7. Taro Kawai
8. B. Beutler

In Microbiology

1. Shizuo Akira
2. K. Takeda
3. Satoshi Uematsu
4. O. Takeuchi
5. B. Beutler
6. B. B. Finlay
7. G. McFadden
8. M. Abreu

Citations in the corpus

• Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. (2004, background): “Conserved microbial pathogen-associated molecular patterns induce chemokines through pattern recognition receptors, such as Toll-like receptors, or the nucleotide-binding site leucine-rich repeat proteins NOD1 and NOD2 (135, 136).”
• The immunomodulatory properties of probiotic microorganisms beyond their viability (ghost probiotics: proposal of paraprobiotic concept) (2011, background): “These differences can be sensed by host PRRs, as shown for NOD1, which specifically detects the presence of meso-DAP in PGN, a signature of Gram-negative bacteria ( Girardin et al. 2003 ).”
• Pathogen recognition and innate immunity. (2006, positive): “NOD1 and NOD2 detect g-D-glutamyl-meso-diaminopimelic acid (iE-DAP) and muramyl dipeptide (MDP), found in bacterial PG, respectively (Figure 4) (Chamaillard et al., 2003; Girardin et al., 2003).”
• Nod-like proteins in immunity, inflammation and disease (2006, background): “In contrast, Nod1 senses peptidoglycan containing meso -diaminopimelic acid ( meso -DAP), which is more commonly found in Gram-negative bacteri”
• A critical role of RICK/RIP2 polyubiquitination in Nod‐induced NF‐κB activation (2008, background): “Two NLR family members, Nod1 and Nod2, play an essential role in the recognition of specific bacterial peptidoglycan (PGN)- related molecules (Chamaillard et al, 2003; Inohara et al, 2003; Girardin et al, 2003a, b).”
• Small Molecules from the Human Microbiota (2015, positive): “One example is muramyl dipeptide, a glycopeptide fragment of the repeating unit of peptidoglycan, that is a ligand for nucleotide-binding oligomerization domain–containing protein 2 (NOD2) and forms the scaffold for the immune-stimulatory osteosarcoma drug mifamurtide (71, 72).”
• Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses (2009, background): “Whereas NOD1 recognizes diaminopimelic acid produced primarily by gram-negative bacteria (53, 101), NOD2 is activated by muramyl dipeptide (MDP), a component of both gram-positive and -negative bacteria (102).”
• NOD2 is a negative regulator of Toll-like receptor 2–mediated T helper type 1 responses (2004, background): “NOD1, a close relative of NOD2, probably has a similar function through the ability of its LRR to recognize another derivative of PGN, γ-D-glutamyl- meso -diaminopimelic acid (iE-DAP”