Critical review of the role of HTS in drug discovery.

By R. Macarron. 2006

234 citations recorded by the source corpus.

Subfields: Computational Theory and Mathematics, Economics and Econometrics, Reproductive Medicine

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Computational Theory and Mathematics

1. Philip J. Hajduk
2. R. Kavlock
3. J. Greer

In Economics and Econometrics

1. Philip J. Hajduk
2. J. Greer

In Reproductive Medicine

1. Philip J. Hajduk
2. J. Greer

Citations in the corpus

• Novel trends in high-throughput screening. (2009, unknown): “Novel processes for lead discovery Screening of chemical libraries via the processes of HTS and uHTS is a relatively new discipline that started about 10–15 years ago [5 ,6] with initial attempts to screen collections of natural products/extracts [20].”
• The ToxCast program for prioritizing toxicity testing of environmental chemicals. (2007, background): “Thus, the primary driver transforming drug discovery has been HTS technologies (Macarron, 2006).”
• A decade of fragment-based drug design: strategic advances and lessons learned (2007, background): “To improve the chances of finding agents that are active against these targets, technologies such as combinatorial chemistry and ultra-high-throughput screening (HTS) approaches have considerably expanded the numbers of compounds that can be evaluated for their biological activit”