Novel trends in high-throughput screening.

By L. Mayr, D. Bojanic. 2009

642 citations recorded by the source corpus.

Subfields: Biophysics, Computational Theory and Mathematics, Molecular Biology

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Citations in the corpus

Small-Molecule Library Subset Screening as an Aid for Accelerating Lead Identification (2014, background): “Compounds in the library fall into three main categories: (1) individual compounds from commercial sources, (2) groups of commercial compounds synthesized around specific chemical scaffolds (these sets number from tens of compounds to more than a thousand compounds), and (3) compounds synthesized fo”
Lessons from the past and charting the future of marine natural products drug discovery and chemical biology (2012, background): “While miniaturization of assays has continued, the reduction in the quantity of neededmaterial for structure elucidation has kept pace to HTS advances (Mayr and Bojanic, 2009).”
Benchmarking platform for ligand-based virtual screening (2016, background): “is demanding in terms of logistics, hardware/software equipment and economical feasibility [2], [3].”
The enumeration of chemical space (2012, methodology): “25 , 26 The assays used for screening are biochemical or cell-culture assays performed in microtiter plates which can be automated to accommodate hundreds to tens of thousands of assays per day.”
PubChem as a public resource for drug discovery (2010, background): “The human genome project has identified about 20,000 to 25,000 genes and an even larger number of transcripts and proteins, which provides great opportunities for drug target investigation [11].”
Rethinking drug design in the artificial intelligence era (2019, background): “A typical HTS deck (10 6 –10 7 compounds) 57,58 , even with the”