Ultrasmall implantable composite microelectrodes with bioactive surfaces for chronic neural interfaces
By T. Kozai, N. Langhals, Paras R. Patel, Xiaopei Deng, Huanan Zhang, Karen L. Smith, Joerg Lahann, Nicholas A. Kotov, Daryl R. Kipke. Nature Materials, 2012
664 citations recorded by the source corpus.
Implantable neural microelectrodes that can record extracellular biopotentials from small, targeted groups of neurons are critical for neuroscience research and emerging clinical applications including brain-controlled prosthetic devices. The crucial material-dependent problem is developing microelectrodes that record neural activity from the same neurons for years with high fidelity and reliability. Here, we report the development of an integrated composite electrode consisting of a carbon-fibre core, a poly(p-xylylene)-based thin-film coating that acts as a dielectric barrier and that is functionalized to control intrinsic biological processes, and a poly(thiophene)-based recording pad. The resulting implants are an order of magnitude smaller than traditional recording electrodes, and more mechanically compliant with brain tissue. They were found to elicit much reduced chronic reactive tissue responses and enabled single-neuron recording in acute and early chronic experiments in rats. This technology, taking advantage of new composites, makes possible highly selective and stealthy neural interface devices towards realizing long-lasting implants.
Subfields: Cellular and Molecular Neuroscience, Electrical and Electronic Engineering, Polymers and Plastics
View Paper: https://www.semanticscholar.org/paper/95f8a36bd5f96433b3c1187417d67af078621c37
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In Cellular and Molecular Neuroscience
In Polymers and Plastics
Citations in the corpus
- Flexible near field wireless optoelectronics as subdermal implants for broad applications in optogenetics (2017, neutral): “Techniques in electrical brain stimulation, based on penetrating or surface mounted electrodes, represent the most traditional means for activating neurons to determine their roles in cognitive function (Campbell et al., 1991; Cogan, 2008; Kozai et al., 2012).”
- Progress Towards Biocompatible Intracortical Microelectrodes for Neural Interfacing Applications (2014, methodology): “Reprinted with permission from [321], Copyright 2012 Nature Publishing Group.”