NF-κB activation by reactive oxygen species: Fifteen years later

By G. Gloire, S. Legrand-Poels, J. Piette. 2006

1,435 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology

View Paper: https://www.semanticscholar.org/paper/95e884fe1bddbbc337bd1bc85b4c64b5061a3e68

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Subash C. Gupta
2. J. López-Novoa
3. M. Nieto
4. Bharat B. Aggarwal
5. T. Paull
6. Simone Reuter

In Immunology

1. Subash C. Gupta
2. J. López-Novoa
3. M. Nieto
4. Bharat B. Aggarwal
5. Bei Zhang
6. Simone Reuter
7. J. Gensel

Citations in the corpus

• ATM Activation by Oxidative Stress (2010, background): “Oxidative stress leads to the activation of NF-κB [87].”
• Inflammation and EMT: an alliance towards organ fibrosis and cancer progression (2009, background): “The resulting increase in oxidative stress plays an important role in inducing an inflammatory state after obstruction, as oxidative stress is a major activator of the NF-kB pathway (Gloire et al, 2006; Fig 3).”
• NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK. (2008, background): “In turn, the increased oxidative stress may further activate NF-κB [73].”
• Macrophage activation and its role in repair and pathology after spinal cord injury. (2015, background): “…the activation process of M1 macrophages, in part, through NF-κB (nuclear factor-kappa light-chainenhancer of activated-B cells) (Brüne et al., 2013), however, specific ROS effects are difficult to discern, mainly due to the nonspecific effects of the antioxidants available (Gloire et al., 2006).”
• Hydrogen peroxide sensing, signaling and regulation of transcription factors (2014, background): “Concerning the most abundant form of NF- κB, the dimer p65–p50, H 2 O 2 is considered a modulator of activation induced by other agents, namely cytokines, and not an inducer per se [ 22 , 115 , 263 ].”
• Oxidative stress, inflammation, and cancer: how are they linked? (2010, background): “The mechanism for activation of NF-κB by ROS is not clear, and the relationship between NF-κB and ROS is complex [123].”
• TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration (2008, background): “CXCL2 expression induced by the endotoxin lipopolysaccharide and tumor necrosis factor-α, known as physiological stimulators of the ROS pathwa”